Evidence map›Paper›PMID 41131759›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[HDAC2-mediated H3K27 acetylation promotes the proliferation and migration of hepatocellular carcinoma cells].

Shaohai Tang, Baoming Yang, Jiankun Li, Lili Zhao, Yifan Wang, Shunxiang Wang

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shaohai TangDepartment of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Baoming YangDepartment of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Jiankun LiDepartment of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Lili ZhaoCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Yifan WangDepartment of Colorectal Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Shunxiang WangDepartment of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the specific mechanism of histone deacetylase 2 (HDAC2) mediated histone H3 lysine 27 acetylation (H3K27ac) modification in promoting the proliferation and migration of hepatocellular carcinoma cells.

methodsSamples of 40 cases of hepatocellular carcinoma and paracancerous tissues resected from January 2021 to January 2023 were collected. The expressions of HDAC2 and H3K27ac in hepatocellular carcinoma, paracancerous tissues and cell lines were detected by immunohistochemistry and Western blotting. The correlation between the expression levels of HDAC2 and H3K27ac and the relationship between HDAC2 expression and clinicopathological characteristics of patients with hepatocellular carcinoma were analyzed. The proliferation, migration and invasion of Hep3B and HepG2 cells were determined by MTS, clone formation, scratch and Transwell experiments. The acetylation of H3K27 mediated by HDAC2 was verified by Western blotting, real-time fluorescence quantitative PCR (qRT-PCR) and chromatin immunoprecipitation high-throughput sequencing (ChIP-seq).

resultsHigh expression of HDAC2 and low expression of H3K27ac were found in hepatocellular carcinoma tissues and cell lines (

conclusionHDAC2 initiates PI3K/PTEN/AKT/mTOR signal pathway by mediating H3K27 acetylation, which promotes the occurrence and development of hepatocellular carcinoma.

Indexed as

Carcinoma, HepatocellularCell MovementCell ProliferationHistone Deacetylase 2HistonesLiver NeoplasmsAcetylationAnimalsCell Line, TumorFemaleHep G2 CellsHumansLysineMaleMiceMice, NudeHDAC2 protein, humanHistone Deacetylase 2HistonesLysinePTEN PhosphohydrolaseHepatocellular carcinomaHistone deacetylase 2Histone H3 lysine 27 acetylationMigrationProliferation

Identifiers

PMID41131759
PMCPMC12549347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.