Evidence map›Paper›PMID 41131691›Full record

ReviewEuropean journal of clinical investigation2026

Revisiting tricuspid regurgitation: Historical insights and emerging research perspectives.

Claudia Gonzalez-Cucharero, Gemma Vilahur, Marta Saura, Rocío Hinojar, Jose L Zamorano, Carlos Zaragoza

Abstract readReview
In one paragraph

Review in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Novel Minimally Invasive Porcine Model of Functional Tricuspid Regurgitation.Journal of cardiovascular development and disease · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claudia Gonzalez-CuchareroUnidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria Hospital Ramon y Cajal (IRYCIS), Madrid, Spain.
Gemma VilahurCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Marta SauraCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Rocío HinojarCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Jose L ZamoranoCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Carlos ZaragozaUnidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria Hospital Ramon y Cajal (IRYCIS), Madrid, Spain.ORCID https://orcid.org/0000-0002-1706-8592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTricuspid regurgitation (TR), defined as the failure of proper leaflet coaptation during systole, is a common but often underrecognized valvular disorder. TR continues to rise, primarily due to population aging and the broader application of advanced diagnostic imaging techniques. Recent studies have established a clear association between TR and increased morbidity and mortality, thereby challenging its historical perception as a benign condition.

methodsThe development of novel interventional therapies, combined with enhanced insight into the pathophysiology of right-sided heart failure, has prompted a shift towards earlier diagnosis and more proactive clinical management.

aimSeveral gaps between novel scientific advancements and clinical translation still make this disease deserving of further attention. DISCUSSION AND

conclusionIn this review, we examine the most recent advances in understanding TR, which have enabled improved segmentation of affected patient populations. This progress has made it possible to identify key prognostic markers-particularly those related to disease progression-allowing for more accurate risk stratification and significantly more personalized treatment approaches.

Indexed as

Tricuspid Valve InsufficiencyDisease ProgressionEchocardiographyHumansPrognosisTricuspid Valvearrhythmiasimagingmolecular markerspatient stratificationprognostic markerstricuspid regurgitationtricuspid valve

Identifiers

PMID41131691
PMCPMC12817247

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.