SynthesisJournal of applied research in intellectual disabilities : JARID2025
Early Markers for Dementia in the Intellectual Disability Population: A Systematic Literature Review.
Synthesis in Journal of applied research in intellectual disabilities : JARID, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early Markers for Dementia in the Intellectual Disability Population: A Systematic Literature Review.Journal of applied research in intellectual disabilities : JARID · 2025Pooled it
- 'Name It to Tame It': Dementia Diagnostic Procedure in Austrian Care Facilities for People With Intellectual Disabilities. An Interview Study.Journal of intellectual disability research : JIDR · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdults with intellectual disability, especially those with Down syndrome, are at increased risk of dementia. Whilst memory decline is often considered the earliest symptom, emerging research indicates decline in language, executive function, and non-cognitive domains may also occur early, potentially before memory changes.
methodA systematic review using narrative synthesis was conducted to evaluate recent literature on early symptoms of dementia and the trajectory of decline in people with intellectual disabilities and Down syndrome.
resultsEighteen peer-reviewed studies met the inclusion criteria. Early decline was observed across multiple domains, with memory and executive function frequently identified as sensitive to early decline. Attention, mobility, and behaviour were also commonly reported.
conclusionThe findings suggest that early dementia symptoms extend beyond memory decline, highlighting the need to broaden current assessment guidelines. Further research is required to address methodological limitations and improve early detection in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.