Evidence map›Paper›PMID 41131571›Full record

ArticleNutrition & metabolism2025

DASH diet as a preventive strategy for sarcopenia: integrated observational and mendelian randomization analyses in US adults.

Jiayi Zheng, Xiaofeng Chen, Ruihan Peng, Bo Li, Yiting Lin, Xianbin Cai

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PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiayi Zheng *Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
Xiaofeng Chen *Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
Ruihan PengDepartment of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
Bo LiShenzhen University Affiliated South China, Shenzhen, 518000, Guangdong, China.
Yiting LinDepartment of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
Xianbin CaiDepartment of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China. cxbin1@qq.com.

Funding

the Elite Scientists Sponsorship Program by the First Affiliated Hospital of Shantou University Medical College NO.YCTJ-2023-7
6 · The paper itself

Abstract

backgroundDespite the potential of dietary patterns as modifiable interventions, most studies focus on single nutrients and the epidemiological evidence on combined dietary patterns and sarcopenia remains inconclusive.

objectiveBased on NHANES data from 2011 to 2018, we systematically assessed the dose-response relationship between five dietary indices (DASHI, MEDI, AHEI, DII, HEI-2020) and sarcopenia, aiming to provide an evidence-based basis for the development of nutritional intervention strategies.

methodsDietary indices were calculated based on 24-hour dietary questionnaire recall and sarcopenia was assessed by ASMBMI. Weighted multivariate logistic regression models adjusted for sociodemographic, lifestyle, and clinical covariates were applied. Restricted cubic splines were used to test for non-linear relationships. The potential causal relationship between dietary components and sarcopenia was further analyzed using MR.

resultsAmong 6,210 participants (491 with sarcopenia), higher DASHI scores demonstrated a dose-response protective effect. In the fully adjusted model, the DASHI continuous score was negatively associated with the risk of sarcopenia (OR = 0.83, 95% CI: 0.72–0.95, P = 0.008). Quartile trend tests were significant (P for trend = 0.018), with a 50% reduction in risk in the highest quartile (Q4) compared to Q1 (OR = 0.50, 95% CI: 0.30–0.84, P = 0.011). With regard to dietary components, macronutrients (energy, carbohydrates, proteins, fats), B vitamins, vitamin D, calcium and magnesium were found to be protective against sarcopenia (P < 0.05). Causal associations between multiple dietary components and features associated with sarcopenia by MR analysis were consistent with the DASH diet structure.

conclusionThe DASH diet demonstrates a robust inverse association with sarcopenia, likely mediated by its anti-inflammatory properties and nutrient synergy. These findings prioritize DASH-based interventions for high-risk populations. It may help reduce the healthcare burden imposed by sarcopenia. STATEMENT OF SIGNIFICANCE: This study is pioneering in its use of nationally representative data to systematically compare the effects of multiple dietary indices on sarcopenia, providing a high-quality, evidence-based foundation for the development of prevention guidelines based on overall dietary composition.

Indexed as

DASH dietDietary patternsDiet interventionMendelian randomizationNHANESSarcopenia

Identifiers

PMID41131571
PMCPMC12551269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.