Evidence map›Paper›PMID 41131552›Full record

ReviewMalaria journal2025

The usual suspect-malaria? Diagnostic challenges in post-artesunate delayed haemolysis: a clinical laboratory perspective through a case report.

Eva Molnar, Pedro M Cabral, Francisco Portal, André Rodrigues Guimarães, Lurdes Santos, João Tiago Guimarães

Abstract readCase ReportsReview
In one paragraph

Review in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eva MolnarServiço de Patologia Clínica, Hospital Universitário de São João, Unidade Local de Saúde São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal. eva.molnar@ulssjoao.min-saude.pt.
Pedro M CabralServiço de Patologia Clínica, Hospital Universitário de São João, Unidade Local de Saúde São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Francisco PortalUnidade de Farmacologia Clínica, Hospital Universitário de São João, Unidade Local de Saúde de São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
André Rodrigues GuimarãesServiço de Doenças Infeciosas, Hospital Universitário de São João, Unidade Local de Saúde de São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Lurdes SantosServiço de Doenças Infeciosas, Hospital Universitário de São João, Unidade Local de Saúde de São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
João Tiago GuimarãesServiço de Patologia Clínica, Hospital Universitário de São João, Unidade Local de Saúde São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria, a potentially fatal infectious disease, remains a significant global health concern, mainly in tropical regions. In Europe, its incidence is currently low and predominantly travel-related. Thus, a timely diagnosis requires healthcare teams to consider malaria in their differential diagnoses and obtain a thorough travel history. In medical laboratories, despite the present low case numbers, professionals must maintain a high diagnostic proficiency through continuous training and adherence to quality assurance programmes. First-line anti-malarial treatment with artemisinin derivatives is highly effective when implemented in a timely manner. However, as a consequence of their efficacy, a predictable haemolytic phenomenon may occur in some cases, which may be difficult to distinguish from manifestations of the disease itself. This mini review examines a case of travel-associated malaria to highlight diagnostic challenges from a medical laboratory perspective, with a particular focus on post-artesunate delayed haemolysis (PADH), a rare but potentially severe complication of malaria treatment.

Indexed as

AntimalarialsArtemisininsArtesunateHemolysisMalariaHumansMaleTravelAntimalarialsArtemisininsArtesunate

Identifiers

PMID41131552
PMCPMC12548174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.