Splenic artery embolization in a patient with advanced Caroli's syndrome complicated by portal hypertension: a case report.

Ahmad Zohud, Mousa Akram, Yazan Khamaise, Ajwad Khamaise, Qusay Abdoh

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Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Congenital hepatic fibrosis and related ciliopathies across the life course: current management, disease burden, and unmet needs in the era of genomic diagnosis and translational therapeutics.Frontiers in pediatrics · 2026
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5 · Who and what money

Authors and funding

5 authors.

Ahmad ZohudDepartment of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine. zahmadsamerstu@gmail.com.ORCID http://orcid.org/0009-0002-1109-6645

Mousa AkramDepartment of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Yazan KhamaiseDepartment of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Ajwad KhamaiseDepartment of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Qusay AbdohDepartment of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaroli's disease is an inherited disorder characterized by dilatation of intrahepatic bile ducts and congenital hepatic fibrosis. Caroli's disease is complicated by choledocholithiasis, cholangitis, and portal hypertension. CASE PRESENTATION: A 28-year-old Palestinian female with 7-year history of Caroli's disease complicated by liver cirrhosis, portal hypertension, and esophageal varices presented with hypersplenism and thrombocytopenia. She was managed with splenic artery embolization, which improved her platelet count. The splenic artery embolization was complicated by postembolization syndrome, and she was treated with antibiotics and supportive care. Two months later, she died owing to liver encephalopathy and spontaneous bacterial peritonitis.

conclusionThis case highlights the role of splenic artery embolization in managing hypersplenism associated with Caroli's disease. Despite improvement in platelet count, post-embolization syndrome remains a significant risk. Early liver transplantation should be considered in patients with advanced Caroli's syndrome to improve long-term outcomes.

Indexed as

Caroli DiseaseEmbolization, TherapeuticHypersplenismHypertension, PortalSplenic ArteryAdultEsophageal and Gastric VaricesFatal OutcomeFemaleHumansLiver CirrhosisThrombocytopeniaCaroli’s diseaseCaroli’s syndromeCase reportHypersplenismPortal hypertensionSplenic artery embolization

Identifiers

PMID41131542

DOI10.1186/s13256-025-05516-4

PMCPMC12551309

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LicenceCC BY-NC-ND

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