Evidence map›Paper›PMID 41131424›Full record

ArticleEMBO molecular medicine2025

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay.

Aigerim Aidarova, Marieke Carels, Mira Haegman, Yasmine Driege, Steven Timmermans, Eline Van Damme, Javier Aguilera-Lizarraga, Maria Francesca Viola, Rita de Cássia Collaço, Joan Manils and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aigerim AidarovaCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.
Marieke CarelsCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0980-6153
Mira HaegmanCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.ORCID http://orcid.org/0000-0002-4883-312X
Yasmine DriegeCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.
Steven TimmermansDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Eline Van DammeCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.ORCID http://orcid.org/0009-0000-4280-0469
Javier Aguilera-LizarragaCenter of Intestinal Neuroimmune Interaction, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Maria Francesca ViolaCenter of Intestinal Neuroimmune Interaction, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0660-9506
Rita de Cássia CollaçoDepartment of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-2826-1603
Joan ManilsImmunity, Inflammation and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
Steven C LeyInstitute of Immunity & Transplantation, University College London, London, NW3 2PP, UK.ORCID http://orcid.org/0000-0001-5911-9223
Frank BosmansDepartment of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0451-6050
Tom Van de WieleCenter for Microbial Ecology and Technology (CMET), Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
Guy BoeckxstaensCenter of Intestinal Neuroimmune Interaction, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Claude LibertDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-6408-036X
Rudi Beyaert *Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium. rudi.beyaert@irc.vib-ugent.be.ORCID http://orcid.org/0000-0002-5704-582X
Inna S Afonina *Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium. inna.afonina@irc.vib-ugent.be.ORCID http://orcid.org/0000-0001-8894-5305

Funding

Fonds Wetenschappelijk Onderzoek (FWO) 12Z3922NFonds Wetenschappelijk Onderzoek (FWO) 3G086521Fonds Wetenschappelijk Onderzoek (FWO) 3G0I1422Fonds Wetenschappelijk Onderzoek (FWO) G000220NFonds Wetenschappelijk Onderzoek (FWO) G035517NFonds Wetenschappelijk Onderzoek (FWO) G0A7T24NGhent University grant GOA 01G00419Methusalem 01M00121Stichting Tegen Kanker (Fondation Contre le Cancer) 365C06721Strategic Basic Research grants from FWO 3179K5620Strategic Basic Research grants from FWO 3S003122Universiteit Gent (UGent) 2024/01/511Wellcome TrustWellcome Trust Investigator 222487/Z/21/Z
6 · The paper itself

Abstract

CARD14 is an intracellular NF-κB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC). However, its function in the intestine remains unknown. We demonstrate here that transgenic mice expressing the psoriasis-associated gain-of-function human CARD14(E138A) mutant specifically in IEC show mild intestinal inflammation, without epithelial damage. Moreover, CARD14(E138A)

Indexed as

CARD Signaling Adaptor ProteinsEpithelial CellsGuanylate CyclaseInflammationIntestinal MucosaIntestinesMembrane ProteinsSignal TransductionAnimalsDisease Models, AnimalGene Expression ProfilingHumansMiceMice, TransgenicCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseMembrane ProteinsCARD14 SignalingInflammationIntestinal MotilityMALT1Paneth Cells

Identifiers

PMID41131424
PMCPMC12686530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.