Evidence map›Paper›PMID 41131418›Full record

ArticleCell biology and toxicology2025

ATG5-dependent autophagy in Sertoli cells protects against cadmium-disrupted blood-testis barrier via perturbing CXCL2/CXCR2 axis.

Hao Li, Yi-Fan Hu, Xin-Run Wang, Jing-Wen Hong, Zhi-Yang Zhang, Yu-Hui Zou, Xin-Yi Cheng, Ye-Xin Luo, Xu-Dong Zhang, Hua-Long Zhu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hao Li *Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Yi-Fan Hu *Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Xin-Run WangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Jing-Wen HongDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Zhi-Yang ZhangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Yu-Hui ZouDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Xin-Yi ChengDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Ye-Xin LuoDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Xu-Dong ZhangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Hua-Long ZhuDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Yong-Wei XiongDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Wei ChangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China.
Hua WangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China. wanghuadev@ahmu.edu.cn.
Lan YangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230000, China. lilylan5930@sina.com.

Funding

National innovation and entrepreneurship training program for college students 202310366008National Natural Science Foundation of China 82273664Postgraduate Innovation Research and Practice Program of Anhui Medical University YJS20230105Top Talent Support Program for young and middle-aged people of Wuxi Health Committee HB2023082
6 · The paper itself

Abstract

The blood-testis barrier (BTB), a unique structure established through intercellular connections of Sertoli cells, establishes a protective microenvironment for spermatogenesis and male fertility. Cadmium (Cd), known for its toxicity, is ubiquitously present in the environment. Here, our findings revealed that Cd exposure compromises BTB integrity, as demonstrated by decreased expression of BTB-associated proteins and elevated D

Indexed as

AutophagyAutophagy-Related Protein 5Blood-Testis BarrierCadmiumChemokine CXCL2Receptors, Interleukin-8BSertoli CellsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSpermatogenesisAtg5 protein, mouseAutophagy-Related Protein 5CadmiumChemokine CXCL2Cxcl2 protein, mouseCxcr2 protein, mouseReceptors, Interleukin-8BATG5AutophagyBlood-testis barrierCadmiumCXCL2/CXCR2 axis

Identifiers

PMID41131418
PMCPMC12549740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.