ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
A commercial bacteriophage cocktail failed to decolonize Zophobas morio larvae and promoted overgrowth of an OXA-48-producing Salmonella enterica.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Humanizing Zophobas morio larvae microbiota for rapid screening of emerging decolonization strategies against multidrug-resistant bacteria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
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Abstract
purposeEffective decolonization strategies for intestinal carriers of carbapenem-resistant Enterobacterales are essential to prevent severe life-threatening infections. In this work, we established gut colonization in Zophobas morio larvae (ZmL) using an OXA-48-producing Salmonella enterica ST198 strain (Sk-1) and assessed the commercial INTESTI bacteriophage cocktail (INTESTIbc) for decolonization.
methodsZmL were fed with food contaminated with Sk-1 (INTESTIbc-susceptible) for 3 days and then maintained on a non-contaminated diet until day 14 (T14). At T3, ZmL were grouped in untreated, dPBS- or INTESTIbc-treated (oral force-feeding on T3 and T5). At specified intervals, ZmL were sampled for quantification and characterization of Sk-1 (antibiotic/INTESTIbc susceptibility and whole-genome sequencing). ZmL microbiota was also investigated by 16S rRNA amplicon sequencing.
resultsZmL were rapidly colonized by Sk-1 across all groups (T3: 4.3 × 10
conclusionsZmL can be used as a new in vivo model of intestinal colonization with S. enterica. However, INTESTIbc administration failed to achieve decolonization and instead promoted hazardous overgrowth of the inoculated pathogen. These findings highlight the need for further investigations to clarify the therapeutic potential or possible risks of broad-spectrum bacteriophage cocktails against intestinal infections/colonization caused by hyperepidemic S. enterica clones.
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