Evidence map›Paper›PMID 41131367›Full record

ArticleNature microbiology2025

A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people.

Caitlin Welsh, Princess R Cabotaje, Vanessa R Marcelino, Thomas D Watts, Duncan J Kountz, Marion Jespersen, Jodee A Gould, Nhu Quynh Doan, James P Lingford, Thilini Koralegedara and 20 more

Abstract read
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Electrochemical characterization of C. pasteurianum hydrogenase II and three site-directed variants: catalysis and inhibition.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  4. Synthesis of diiron subcluster [FeNature protocols · 2026
    Review
  5. Review
  6. Review
  7. An electron transport complex required in the gut sensitizesProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Caitlin WelshDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. cait.welsh@monash.edu.ORCID http://orcid.org/0009-0000-1720-5246
Princess R CabotajeDepartment of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Vanessa R MarcelinoMelbourne Integrative Genomics, School of BioSciences, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-1755-0597
Thomas D WattsDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-3657-8790
Duncan J KountzDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7824-0261
Marion JespersenDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jodee A GouldCentre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Nhu Quynh DoanDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
James P LingfordDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Thilini KoralegedaraDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jessica SolariDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Gemma L D'AdamoCentre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Ping HuangDepartment of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-7676-6905
Natasha BongDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Emily L GulliverCentre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-1820-6619
Remy B YoungCentre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Henrik LandDepartment of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3073-5641
Kaija WalterDepartment of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0009-0004-6725-028X
Isaac CannCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0003-0539-0119
Gabriel V PereiraDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7937-474X
Eric C MartensDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6681-2990
Patricia G WolfCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Jason M RidlonCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0001-5813-099X
H Rex GaskinsCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-1249-535X
Edward M GilesCentre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-3295-1575
Dena LyrasDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-2345-9271
Rachael LappanDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-3543-8243
Gustav BerggrenDepartment of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-6717-6612
Samuel C ForsterCentre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research, Clayton, Victoria, Australia. sam.forster@hudson.org.au.ORCID http://orcid.org/0000-0003-4144-2537
Chris GreeningDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. chris.greening@monash.edu.ORCID http://orcid.org/0000-0001-7616-0594

Funding

Department of Education and Training | Australian Research Council (ARC) DE220100965Department of Education and Training | Australian Research Council (ARC) DE230100542Department of Education and Training | Australian Research Council (ARC) FL210100258Department of Education and Training | Australian Research Council (ARC) FT240100502Department of Health | National Health and Medical Research Council (NHMRC) APP1178715Energimyndigheten (Swedish Energy Agency) "STEM" 48574-1Novo Nordisk NNF21OC0066716
6 · The paper itself

Abstract

Disruption of hydrogen (H

Indexed as

BacteriaGastrointestinal MicrobiomeGastrointestinal TractHydrogenaseBacillotaBacteroidetesCrohn DiseaseFecesFermentationHealthy VolunteersHumansHydrogenIron-Sulfur ProteinsMetagenomicsHydrogenHydrogenaseIron-Sulfur Proteins

Identifiers

PMID41131367
PMCPMC12578642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.