Evidence map›Paper›PMID 41131277›Full record

ArticleScientific reports2025

Enhanced lymphocyte infiltration in the liver of LDL receptor and Myeloid Differentiation 1 double knockout mice on high fat diet.

Mrityunjoy Biswas, Susumu Tomono, Kenji Kasai, Hidekazu Takagi, Masanori Inui, Bristy Basak, Fumiaki Nagaoka, Tatsuya Yamazaki, Naoko Morita, Akinori Okumura and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mrityunjoy BiswasDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Susumu TomonoDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kenji KasaiDepartment of Pathology, Aichi Medical University, School of Medicine, Nagakute, Aichi, Japan.
Hidekazu TakagiDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Masanori InuiDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Bristy BasakDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Fumiaki NagaokaDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Tatsuya YamazakiDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Naoko MoritaDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Akinori OkumuraDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Sachiko Akashi-TakamuraDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. sachiko@aichi-med-u.ac.jp.

Funding

International Joint Usage/Research Center, the Institute of Medical Science, the University of Tokyo 22-3064JSPS KAKENHI 19K08500
6 · The paper itself

Abstract

Myeloid differentiation 1 (MD-1; gene name: ly86), a glycoprotein that forms a complex with radioprotective protein 105 (RP105), is involved in the regulation of inflammation, obesity, and insulin resistance. Previous reports have shown an exacerbation of cardiac pathology in MD-1 deficient mice, including pressure overload-induced cardiac remodeling and high fat diet (HFD) -induced inflammatory atrial fibrosis. Furthermore, MD-1 expression is upregulated in atherosclerosis, as indicated by DEG database analysis, and is present in human atherosclerotic plaques. However, its involvement in atherosclerosis is unclear. In this study, we analyzed the effect of MD-1 deficiency on the development of HFD-induced atherosclerosis in littermates of low-density lipoprotein (LDL) receptor-deficient mice (LDLr

Indexed as

AtherosclerosisDiet, High-FatLiverLymphocytesReceptors, LDLAnimalsMaleMiceMice, KnockoutReceptors, LDLAtherosclerosisB-cell infiltrationly86MD-1Myeloid differentiation 1RP105

Identifiers

PMID41131277
PMCPMC12549959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.