ReviewNature reviews. Neuroscience2025
Central neural circuits underlying itch sensation.
Review in Nature reviews. Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates.Annals of medicine · 2026Article
- Anterior Cingulate Cortex Astrocytes Regulate Chronic Itch and Comorbid Negative Emotional Disorders in Mice.CNS neuroscience & therapeutics · 2026Article
- A prefrontal peptidergic circuit for psychogenic itch.Science advances · 2026Article
- CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic.Nature communications · 2026Article
- Neuro-immune Crosstalk in Atopic Dermatitis: A Multiaxial Regulatory Network and Novel Therapeutic Perspectives.Clinical reviews in allergy & immunology · 2026Review
- Cerebral responses to acupuncture for uremic pruritus: study protocol for a randomized controlled trial based on fNIRS.Frontiers in human neuroscience · 2026Article
- A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Itch represents an important somatosensory defensive mechanism. Both mechanical and chemical pruritic stimuli evoke the sensation of itch, and the molecular mechanisms for its peripheral signal transduction have been revealed. Local neuronal networks in the spinal cord are essential for central processing and gating of these transduced itch signals, which are then transmitted to the brain via several types of spinal projection neuron. Both the thalamus and the parabrachial nucleus are essential for the central relay of itch information. In the brain, several neural circuits between brain areas can use this encoded information to alter affective states, which in turn motivate defensive responses such as scratching behaviour. Itch signal processing in the spinal cord is regulated by both neuromodulatory systems and descending pathways. In this Review, progress in the understanding of the neural circuits that underlie itch signal processing, transmission and encoding within the CNS is synthesized. Neural circuit mechanisms in the brain for itch perception and the modulation of itch processing in the spinal cord via descending and neuromodulatory pathways are also discussed.
Indexed as
Identifiers
41131169What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.