Evidence map›Paper›PMID 41131083›Full record

ArticleScientific reports2025

Protective effect of astaxanthin on myocardial injury induced by autologous liver transplantation in rats in conjunction with the Nrf2/HO-1 pathway.

Shujun Lu, Yajing Zhang, Yiqi Weng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shujun LuDepartment of Anesthesiology, Tianjin First Central Hospital, Tianjin, 300192, China.
Yajing ZhangDepartment of Anesthesiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin, 300193, China. zhangyajing1128@163.com.
Yiqi WengDepartment of Anesthesiology, Tianjin First Central Hospital, Tianjin, 300192, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated astaxanthin's cardioprotective effects in rat autologous orthotopic liver transplantation. Male Wistar rats received astaxanthin (500 mg/kg) for two weeks before transplantation, with controls including sham, transplant-only, and astaxanthin plus all-trans retinoic acid groups. Astaxanthin pre-conditioning significantly reduced myocardial injury markers: IL-6 decreased 2.3-fold, cTnI decreased 1.8-fold, and TNF-α decreased 2.1-fold versus transplant controls. SOD activity increased 1.6-fold while MDA levels decreased 2.4-fold. The Bcl-2/Bax ratio improved 2.2-fold. All-trans retinoic acid negated these protective effects. Astaxanthin pre-conditioning alleviated myocardial injury via the Nrf2/HO-1 pathway, demonstrating therapeutic potential for cardiac protection during liver transplantation.

Indexed as

Cardiotonic AgentsHeme Oxygenase-1Liver TransplantationNF-E2-Related Factor 2AnimalsHeme Oxygenase (Decyclizing)MaleMyocardiumOxidative StressRatsRats, WistarSignal TransductionXanthophyllsastaxanthineCardiotonic AgentsHeme Oxygenase-1Heme Oxygenase (Decyclizing)Hmox1 protein, ratNfe2l2 protein, ratNF-E2-Related Factor 2XanthophyllsAstaxanthinLiver transplantationMyocardial injuryNrf2/HO-1

Identifiers

PMID41131083
PMCPMC12549905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.