ArticleScientific reports2025
Bioactive compounds and therapeutic potential of Salvia fruticosa Mill. leaves against microorganisms and osteosarcoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Many studies reported the cytotoxic effect of Salvia fruticosa Mill. (S. fruticosa) on different cancer cell lines. This study aims to investigate the methanolic extract of S. fruticosa leaves in terms of its polyphenolic content, antioxidant activity, antimicrobial activity against different microorganisms, and cytotoxic activities on the U2OS osteosarcoma cell line. Fourier Transform Infrared Spectroscopy was performed to detect the major functional groups in the extract. The extract's total carbohydrate content was found to be 45.63 ± 3.33 mg glucose equivalent, the total phenolic content was 170.68 ± 6.52 mg caffeic acid equivalent, and the total flavonoid content was 44.71 ± 5.67 mg rutin equivalent per gram of the extract. Polyphenolic bioactive compounds of the extract were identified and quantified using Liquid chromatography-electrospray ionization-tandem mass spectrometry, demonstrating that naringenin is the most abundant polyphenolic compound, quantified at 3137.22 µg of the standard per gram of the extract. The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity assay, revealing an IC
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