ArticleNature communications2025
Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- A pleiotropic single-molecule, sustained-release regenerative scaffold enables coordinated repair after ischemic stroke.Bioactive materials · 2026Article
- Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biomedical Materials and Fabrication Methods for Construction of In Vitro Neurovascular Unit Models.Materials (Basel, Switzerland) · 2026Review
- Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multifunctional composite microgels: From structural design to biomedical applications.Materials today. Bio · 2026Review
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Impact of the Chronic Ischemic Stroke Microenvironment on Silk Fibroin Hydrogel Biodegradation andACS omega · 2026Article
- Three-dimensional bioprinted hiHeps hepatorganoids with enhanced hepatic functions for the treatment of liver failure and promotion of liver regeneration.Bioactive materials · 2026Article
- Stimuli-responsive nanozyme-hydrogel systems for ischemic stroke: toward spatiotemporal catalytic control of the neurovascular unit.Frontiers in neurology · 2026Review
- Stem cell therapy for stroke: mechanisms, clinical translation, and future perspectives.Frontiers in cellular neuroscience · 2026Review
- Engineered Exosomal miRNAs for Post-Stroke Neural Repair: Mechanisms, Delivery Strategies, and Translational Challenges.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Stem cell therapy for stroke is hindered by poor cell survival and integration within the ischemic microenvironment. Injectable microgels have been widely employed in cell delivery for their ability to promote cell infiltration, but dense hydrogel networks often limit cell survival. Here we present an injectable microgel-matrix composite scaffold that combines microporous microgels for neural progenitor cells (NPCs) delivery with interstitial spaces to support vascular growth. Using a gas-shearing fabrication approach, primary rat NPCs are efficiently encapsulated in phase-separated microporous microgel (PSMM), exhibiting superior survival and proliferation. In vitro studies demonstrate that PSMM scaffolds support endothelial cell (EC) sprouting and vascular formation, and in ischemic stroke rats, this formulation significantly enhance NPC loading capacity, survival, and differentiation, along with increased EC proliferation and infiltration. Ultimately, the microgel-matrix scaffold enhances long-term neurological recovery in stroke models, offering an efficient strategy that couples high cell loading with vascularization to advance regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.