ArticleNature communications2025
AgentMD: Empowering language agents for risk prediction with large-scale clinical tool learning.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Development of an LLM pipeline exceeding physician-documented cardiovascular risk scores under routine clinical conditions.European heart journal. Digital health · 2026Article
- A comprehensive survey of AI agents in healthcare.Journal of biomedical informatics · 2026Review
- A real-world feasibility evaluation of LLM-based clinical prediction: emergency department return visit admission across two academic medical centers.Research square · 2026Article
- Model confrontation and collaboration: A debate intelligence framework for enhancing medical reasoning in large language models.Cell reports. Medicine · 2026Article
- Medea: An omics AI agent for therapeutic discovery.bioRxiv : the preprint server for biology · 2026Article
- Are artificial intelligence (AI) agents ready for medicine and biomedical research? A narrative review.Journal of Yeungnam medical science · 2026Article
- DynamiCare: A Dynamic Multi-Agent Framework for Interactive and Open-Ended Medical Decision-Making.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026Article
- State of clinical AI in 2026.BMJ digital health & AI · 2026Review
- AgentMD: Empowering language agents for risk prediction with large-scale clinical tool learning.Nature communications · 2025Article
- SepsisCalc: Integrating Clinical Calculators into Early Sepsis Prediction via Dynamic Temporal Graph Construction.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2025Article
- A perspective for adapting generalist AI to specialized medical AI applications and their challenges.NPJ digital medicine · 2025Review
- Automated computation of the HEART score with the GPT-4 large language model.The American journal of emergency medicine · 2025Article
- Large language model agents can use tools to perform clinical calculations.NPJ digital medicine · 2025Article
- Leveraging artificial intelligence to reduce diagnostic errors in emergency medicine: Challenges, opportunities, and future directions.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Review
- Article
- Humans and Large Language Models in Clinical Decision Support: A Study with Medical Calculators.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
Clinical calculators play a vital role in healthcare, but their utilization is often hindered by usability and dissemination challenges. We introduce AgentMD, a novel language agent capable of curating and applying clinical calculators across various clinical contexts. As a tool builder, AgentMD first uses PubMed to curate a diverse set of 2,164 executable clinical calculators with over 85% accuracy for quality checks and over 90% pass rate for unit tests. As a tool user, AgentMD autonomously selects and applies the relevant clinical calculators. Our evaluations show that AgentMD significantly outperforms GPT-4 for risk prediction (87.7% vs. 40.9% in accuracy). Results on 698 real-world emergency department notes confirm that AgentMD accurately computes medical risks at an individual level. Moreover, AgentMD can provide population-level insights for institutional risk management. Our study illustrates the capabilities of language agents to curate and utilize clinical calculators for both individual patient care and at-scale healthcare analytics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.