Evidence map›Paper›PMID 41130918›Full record

ReviewAnnual review of microbiology2025

Pathogenic Fungal Sensing and Responses to Stressful Host Environments.

Jackson R Rapala, Faith Anderson Davis, Ajay Larkin, Teresa R O'Meara

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jackson R RapalaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email: tromeara@umich.edu.
Faith Anderson DavisDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email: tromeara@umich.edu.
Ajay LarkinDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email: tromeara@umich.edu.
Teresa R O'MearaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email: tromeara@umich.edu.

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Microbial Corrinoid Metabolism Across Scales: From Molecular Specificity to Community DynamicsR35GM139633 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michiko E. Taga · 2021 to 2026
$3.0M
Michigan Predoctoral Training in GeneticsT32GM149391 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN V. MORAN · 2024 to 2026
$2.2M
Discovery of gene function and dissection of network re-wiring in non-model fungiR35GM147894 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Teresa R. OMeara · 2022 to 2026
$2.0M
NIAID NIH HHS T32 AI007528NIGMS NIH HHS R35 GM139633NIGMS NIH HHS R35 GM147894NIGMS NIH HHS T32 GM149391
6 · The paper itself

Abstract

Despite the ubiquity of fungi in nature, only a small fraction are pathogenic to humans, and the majority of these fungi are opportunistic and affect immunocompromised individuals. In general, pathogen emergence is restricted by the ability of fungi to sense and withstand human host environmental cues and stresses. These stress responses in fungi involve immediate survival reactions as well as long-term adaptations. Additionally, some opportunistic pathogenic behavior suggests that virulence traits evolved for environmental survival, a concept known as exaptation. This review covers recent advances in examining fungal responses to host environments and focuses on stress pathways including HOG (high osmolarity glycerol) and CWI (cell wall integrity), thermotolerance mechanisms, CO

Indexed as

FungiHost-Pathogen InteractionsMycosesStress, PhysiologicalAdaptation, PhysiologicalAnimalsHumansVirulenceCandida, Aspergillus, Cryptococcusopportunistic pathogensstress response

Identifiers

PMID41130918
PMCPMC12813995

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.