Evidence map›Paper›PMID 41130911›Full record

ArticleCancer reports (Hoboken, N.J.)2025

A Pediatric Case of Hepatocellular Malignant Neoplasm, Not Otherwise Specified (HCN-NOS) With Poor Prognosis Post-Tumor Resection and Postoperative Chemotherapy.

Bin Yamaoka, Reina Hoshi, Kako Ono, Takayuki Hirano, Yosuke Watanabe, Shumpei Goto, Takashi Hosokawa, Shuichiro Uehara

Abstract readCase Reports
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bin YamaokaDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0009-0009-9399-270X
Reina HoshiDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0000-0002-1251-4944
Kako OnoDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0009-0001-2355-3607
Takayuki HiranoDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0009-0007-7629-1886
Yosuke WatanabeDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0009-0007-7142-3878
Shumpei GotoDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0009-0009-7960-8206
Takashi HosokawaDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0009-0005-9541-3434
Shuichiro UeharaDepartment of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.ORCID 0000-0001-6542-3782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatocellular malignant neoplasm, not otherwise specified (HCN-NOS) is a newly identified liver tumor with features of mixed hepatoblastoma (HB) and hepatocellular carcinoma (HCC). Although its prognosis and treatment strategies are not well defined, some reports suggested that complete resection with HB-targeting chemotherapy may yield favorable outcomes. CASE PRESENTATION: We present herein a pediatric case of HCN-NOS in which the tumor was fully resected followed by postoperative chemotherapy. Unfortunately, the patient subsequently died.

conclusionThis case highlights the fact that hepatoblastoma protocols may not always be effective in the treatment of HCN-NOS; therefore, developing treatment strategies tailored to HCN-NOS is crucial to improve patient prognosis.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, HepatocellularHepatoblastomaLiver NeoplasmsAdolescentChemotherapy, AdjuvantFatal OutcomeHepatectomyHumansMalePrognosischildrenhepatoblastomahepatocellular carcinomahepatocellular malignant neoplasm

Identifiers

PMID41130911
PMCPMC12549212

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