ReviewPsycho-oncology2025
Psychosocial Impacts of Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer: A Narrative Review.
Review in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Changing Landscape of Hereditary Diffuse Gastric Cancer.Journal of gastric cancer · 2026Review
- Psychosocial Impacts of Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer: A Narrative Review.Psycho-oncology · 2025Review
- Hereditary Diffuse Gastric Cancer With Poorly Differentiated Gallbladder Adenocarcinoma: A Case Report Suggesting Carcinogenesis in the Stomach and Gallbladder Caused by a Pathogenic Germline Variant inIn vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPathogenic or likely pathogenic (P/LP) CDH1 germline genetic variants are causally linked to early onset diffuse gastric cancer and prophylactic total gastrectomy (PTG) is a recommended intervention for (P/LP) CDH1 variant carriers. However, PTG introduces fundamental challenges to a patient's quality of life (QOL) and psychological well-being. There is a growing need for evidence-based recommendations to address the psychosocial needs of PTG patients. The present review summarizes published literature on psychosocial sequelae and quality of life reported post-PTG in germline (P/LP) CDH1 variant carriers.
methodsArticles were extracted from the PubMed database using the following search terms: "total gastrectomy", "CDH1", "CTNNA1", "guidelines", "psychological", "psychiatric", "mental health", "quality of life", and "longitudinal". Articles that address psychological and QOL implications and outcomes for PTG or total gastrectomy (TG) patients were included. Articles that mentioned "psychosocial factors" generally, without specific details, were excluded.
results37 articles met inclusion criteria. Seven of the most frequently mentioned psychosocial domains in the published literature include quality of life (n = 22), social relationships (n = 12), depression and anxiety (n = 8), decision-making (n = 7), employment and finances (n = 4), body image (n = 5), and substance abuse (n = 3).
conclusionsConsidering the known psychological impact of a genetic cancer predisposition diagnosis and the significant postoperative lifestyle adjustment, this review identifies a need for standardized integration of mental health care along the PTG surgical continuum. The combination of the diagnosis of a hereditary cancer syndrome and the life-altering nature of prophylactic total gastrectomy (PTG) presents a psychosocial vulnerability for CDH1 (P/LP) variant carriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.