Evidence map›Paper›PMID 41130793›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Nuclear Imaging Strategies to Evaluate Cytokine Production in Autoimmune, Inflammatory, and Neoplastic Diseases: A Review of Current Preclinical Research.

Alexander Deck, Savannah Lane, Amber Liles, Nerissa T Viola

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander DeckDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Savannah LaneDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Amber LilesDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Nerissa T ViolaDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan nviola@wayne.edu.

Funding

Delineating Functional Immunity via Image-Guided PETR37CA220482 · NCI · WAYNE STATE UNIVERSITY · PI GIBSON, HEATHER MARIE, VIOLA, NERISSA THERESE · 2018 to 2024
$3.9M
NCI NIH HHS R37 CA220482
6 · The paper itself

Abstract

Cytokines are small proteins that directly regulate immune cell proliferation and signaling. An improved understanding of cytokine expression in specific microenvironments provides critical insights into essential physiologic and pathophysiologic responses to disease and infection. Standard methods used to detect and quantify cytokines are not fully suitable for this purpose, given their limited sensitivity and capacity to address cytokine heterogeneity and short biologic half-lives. In contrast, nuclear imaging modalities (e.g., PET, SPECT) can be used to detect cytokine binding in situ in real time. In this review, we discuss some of the most promising preclinical nuclear imaging agents that have been developed to target specific cytokines. These agents may ultimately be used in the clinical setting to monitor disease progression and responses to treatments for cancer and autoimmune and inflammatory diseases.

Indexed as

Autoimmune DiseasesCytokinesInflammationNeoplasmsRadioisotopesRadionuclide ImagingAnimalsHumansPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonCytokinesRadioisotopescytokinesimmune-related diseasesnuclear imagingPETSPECT

Identifiers

PMID41130793
PMCPMC12676670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.