Evidence map›Paper›PMID 41130742›Full record

ArticleBMJ global health2025

Community versus institutionalised care for people with severe mental illness in five countries in Southeast Europe: pooled analysis of five randomised trials.

Laura Shields-Zeeman, Filip Smit, Ben Wijnen, Catharina Roth, Michel Wensing, Ionela Petrea, RECOVER-E consortium, Felix Bolinski, Stojan Bajraktarov, Jovo Dedovic and 10 more

5 registry-linked trialsAbstract readComparative Study
In one paragraph

Article in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03837340 naunknown statusnot on this map

Large-scale Implementation of Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health in Europe

TypeinterventionalSponsorSpecial Psychiatric Hospital KotorRan2018 to 2022Enrolled160ConditionsSevere Mental Disorders, Schizophrenia, Bipolar Disorder, Severe DepressionArmsCMHT, CAU
NCT03862209 naunknown statusnot on this map

Large-scale Implementation of Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health in Europe

TypeinterventionalSponsorKlinički Bolnički Centar ZagrebRan2018 to 2021Enrolled200ConditionsSevere Mental Disorder, Schizophrenia, Bipolar Disorder, Severe DepressionArmsCommunity mental health team
NCT03884933 naunknown statusnot on this map

Large Scale Implementation of Community Based Mental Health Care for People With Severe and Enduring Mental Ill Health in Europe

TypeinterventionalSponsorLiga Romana pentru Sanatate MintalaRan2019 to 2020Enrolled180ConditionsMental Disorders, SevereArmsMobile team community mental health services
NCT03892473 naunknown statusnot on this map

Large-scale Implementation of Community-based Mental Health Care for People With Severe and Enduring Mental III Health in Europe

TypeinterventionalSponsorUniversity of SkopjeRan2018 to 2022Enrolled160ConditionsSevere Mental Disorder, Schizophrenia, Bipolar Disorder, Severe DepressionArmsCommunity mental health teams (CMHT), Care as usual (CAU)
NCT03922425 naunknown statusnot on this map

Large Scale Implementation of Community Based Mental Health Care for People With Severe and Enduring Mental Ill Health in Europe

TypeinterventionalSponsorThe National Center for Public Health and Analyzes, BulgariaRan2018 to 2022Enrolled180ConditionsBipolar Disorder, Schizophrenia, Severe DepressionArmsCommunity mental health team
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Laura Shields-ZeemanUtrecht University, Utrecht, The Netherlands lshields-zeeman@trimbos.nl.ORCID http://orcid.org/0000-0003-0923-8771
Filip SmitTrimbos Institute, Utrecht, The Netherlands.
Ben WijnenTrimbos Institute, Utrecht, The Netherlands.
Catharina RothDepartment of General Practice and Health Service Research, University Hospital Heidelberg, Heidelberg, Germany.
Michel WensingDepartment of General Practice and Health Service Research, University Hospital Heidelberg, Heidelberg, Germany.
Ionela PetreaINSIGHT International, London, UK.
RECOVER-E consortium
Felix BolinskiTrimbos Institute, Utrecht, The Netherlands.
Stojan BajraktarovUniversity Clinic of Psychiatry, Skopje, North Macedonia.
Jovo DedovicSpecial Psychiatric Hospital Dobrota, Kotor, Montenegro.
René KeetGGZ Noord-Holland-Noord FIT-Academy, Heerhugowaard, The Netherlands.
Martina Rojnic KuzmanUniversity of Zagreb School of Medicine, Zagreb, Croatia.
Vladimir NakovNational Center of Public Health and Analyses, Sofia, Bulgaria.
Raluca NicaRomanian League for Mental Health, Bucharest, Romania.
Antoni NovotniUniversity Clinic of Psychiatry, Skopje, North Macedonia.
Aleksandar TomcukSpecial Psychiatric Hospital Dobrota, Kotor, Montenegro.
Tatjana DjurisicInstitute of Public Health of Montenegro, Podgorica, Montenegro.
Guadalupe MoralesFundación Mundo Bipolar, Madrid, Spain.
Tiberiu Rotaru AnghelescuSiret Psychiatric Hospital, Siret, Romania.
RECOVER-E study

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe RECOVER-E project implemented community-based mental healthcare (CMH) oriented at functional recovery in people with schizophrenia, bipolar and severe major depressive disorder in five countries: Bulgaria, Croatia, Montenegro, North Macedonia and Romania, with the aim to shift care from institutions to communities.

objectiveTo evaluate the effectiveness of CMH under real-world circumstances across various healthcare ecologies and contexts.

methodsA randomised comparison of CMH versus treatment as usual (TAU) based on pooled data from all five RECOVER-E trials (N=931). Outcomes were personal and social role functioning (WHO Disability Assessment Schedule, WHODAS 2.0) and health-related quality of life (EuroQoL-5 Dimensions-3 Levels) at baseline, 12 and 18 months postbaseline. Intention-to-treat analysis was conducted with mixed modelling and a sensitivity analysis adjusted for the impact of COVID-19 on healthcare delivery and outcomes.

findingsAt 18-month follow-up, CMH had a 4.55 lower WHODAS disability score than TAU, which was significant (b=-4.55, SE=1.21, z=-3.75, p<0.001), and improved quality of life by 0.07 utility (b=0.07, SE=0.014, z=4.56, p<0.001) equivalent to an additional 25 days in full health. Similar effects were observed in each of the five countries and for all WHODAS subdomains (cognition, mobility, self-care, getting along with people, life activities, participation). Sensitivity analyses adjusting for the confounding effect of COVID-19 showed similar effects. CLINICAL IMPLICATIONS: Recovery-oriented CMH for people with severe mental illness was effective in improving functioning and quality of life for people with schizophrenia, bipolar disorder and severe depression in five South-Eastern European countries and could be implemented across different health systems. TRIAL REGISTRATION NUMBERS: Bulgaria: NCT03922425, Croatia: NCT03862209, Macedonia: NCT03892473, Montenegro: NCT03837340, Romania: NCT03884933.

Indexed as

Community Mental Health ServicesInstitutionalizationMajor Depressive DisorderMental DisordersAdultBipolar DisorderBulgariaCOVID-19CroatiaFemaleHumansMaleMiddle AgedMulticenter Studies as TopicPragmatic Clinical Trials as TopicQuality of LifeHealth services researchMental Health & PsychiatryRandomised control trial

Identifiers

PMID41130742
PMCPMC12551481

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.