Evidence map›Paper›PMID 41130513›Full record

ArticleThe Journal of investigative dermatology2026

Fibroblast-specific deletion of Tgfbr2 in mouse skin recapitulates human skin dermal aging by suppressing collagen production.

Tianyuan He, Ingrid L Bergin, Jun Young Kim, Chunfang Guo, Cong-Qiu Chu, Gary J Fisher, John J Voorhees, Taihao Quan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianyuan HeDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Ingrid L BerginUnit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jun Young KimDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.
Chunfang GuoDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Cong-Qiu ChuDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, Oregon, USA.
Gary J FisherDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
John J VoorheesDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Taihao QuanDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: thquan@umich.edu.

Funding

YAP/TAZ Regulation of Extracellular Matrix HomeostasisR01AG083378 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARY J FISHER, TaiHao Quan · 2023 to 2026
$2.6M
The impact of the dermal ECM microenvironment on cutaneous aging and cancerR01AG081805 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARY J FISHER, TaiHao Quan · 2023 to 2026
$2.6M
The impact of aged-related dermal microenvironment on the development of precancerous stroma and cancer initiationU01AG077924 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DLUGOSZ, ANDRZEJ A., FISHER, GARY J · 2021 to 2025
$2.3M
CYR61-a novel potential mediator of photoaged human skinR01ES014697 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QUAN, TAIHAO · 2007 to 2010
$1.7M
NIA NIH HHS R01 AG081805NIA NIH HHS R01 AG083378NIA NIH HHS U01 AG077924NIEHS NIH HHS R01 ES014697
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingCollagenDisc degenerationFibroblastTGFBR2

Identifiers

PMID41130513
PMCPMC13094630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.