Evidence map›Paper›PMID 41130320›Full record

ArticleVirus research2025

Higher viremia and pathogenesis of human adenovirus 7 is likely associated to enhanced disruption of junction integrity.

Jing Zhou, Qigao Chen, Bolin Cheng, Lianzhong Li, Yihao Yang, Yongping Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing ZhouDepartment of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Qigao ChenDepartment of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Bolin ChengDepartment of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Lianzhong LiDepartment of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Yihao YangDepartment of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Yongping LinNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, Guangdong, China. Electronic address: 18928868278@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical effects of pediatric human adenovirus (HAdV) 7 infection are more severe than those caused by HAdV-3. This increased pathogenesis is likely associated with a higher viremia, i.e., a higher presence of HAdV-7 in blood, but the mechanisms that explain this are poorly understood. Herein, we tested the polarization of entry and release for both HAdV-7 or HAdV-3 in epithelial and endothelial cells, and evaluated the effect of these viruses on cellular junctions of epithelial cells, measuring transepithelial electrical resistance and paracellular flux. We show that epithelial cells are infected by both viruses via either basolateral or apical sides, but are released apically. In contrast, in endothelials cells, both entry and release can occur from either side. The replication capacity was higher for HAdV-7 than for HAdV-3, and infection led to more severe epithelial barrier damage, compromising tight junction integrity. These effects may be related to the higher viremia observed previously in HAdV-7. The way in which HAdV-7 traverses epithelial and endothelial barriers to establish a new infection offers new perspectives to treat its pathogenicity.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanTight JunctionsViremiaCell LineEndothelial CellsEpithelial CellsHumansVirus InternalizationVirus ReplicationEgressHAdV-3HAdV-7Polarized endothelial and epithelial cellsTight junction protein

Identifiers

PMID41130320
PMCPMC12607036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.