Evidence map›Paper›PMID 41130047›Full record

ArticlePoultry science2025

Performance, digestibility, antioxidant activity, immunity, and zinc bioavailability benefits of advanced zinc chelate supplementation in broiler diets: A comparative study.

Mousa Nasiri, Hossein Ali Ghasemi, Iman Hajkhodadadi, Mohammad Hassan Nazaran

Abstract readComparative Study
In one paragraph

Article in Poultry science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mousa NasiriDepartment of Animal Science, Faculty of Agriculture and Environment, Arak University, Arak, 38156-8-8349, Iran.
Hossein Ali GhasemiDepartment of Animal Science, Faculty of Agriculture and Environment, Arak University, Arak, 38156-8-8349, Iran. Electronic address: h-ghasemi@araku.ac.ir.
Iman HajkhodadadiDepartment of Animal Science, Faculty of Agriculture and Environment, Arak University, Arak, 38156-8-8349, Iran.
Mohammad Hassan NazaranDepartment of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran. Electronic address: mnazaran@nanochelatingtechnology.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effects of various organic sources of zinc at different levels on growth performance, physiological indices, antioxidant status, immunity, and mineral metabolism in broiler chickens. A total of 1,400 one-day-old male chicks were used in a completely randomized design with 10 experimental treatments, each arranged in 5 replicate pens with 28 birds per pen. The treatments included a control diet containing zinc sulfate (ZnSO₄); zinc-methionine supplementation at levels of 40, 80, and 120 mg/kg diet (Zn-Met40, Zn-Met80, and Zn-Met120); zinc-glycine supplementation at similar levels (Zn-Gly40, Zn-Gly80, and Zn-Gly120); and advanced zinc chelate supplementation at corresponding levels (Zn-ACT40, Zn-ACT80, and Zn-ACT120). The results showed that the Zn-ACT80, Zn-ACT120, and Zn-Met80 treatments significantly increased body weight gain, improved feed conversion ratio, and increased performance index compared with the control and Zn-Gly40 treatments (P < 0.05). The Zn-ACT80, Zn-ACT120, Zn-Met80, and Zn-Met120 treatments significantly increased the activity of antioxidant enzymes, including superoxide dismutase and catalase, and increased total serum antioxidant capacity (P < 0.05). Improvements in nutrient absorption and ileal digestion of crude protein were also observed in these treatments. The Zn-ACT80 and Zn-Met120 treatments further increased zinc concentrations in the bone and pancreas and decreased zinc excretion through feces (P < 0.05), indicating higher bioavailability than Zn-Gly at comparable levels. An increase in the number of goblet cells and an improvement in the absorptive surface of the intestinal villi were also reported in the Zn-ACT80 and Zn-Met80 treatments (P < 0.05). From an economic point of view, Zn-ACT80 achieved effectiveness equivalent to, or greater than, that of Zn-ACT120 in many indices. In conclusion, the findings showed that the advanced zinc chelate was comparable to zinc-methionine in terms of bioavailability and effectiveness in improving the performance and health of broilers, and both supplements were superior to zinc-glycine, suggesting the use of advanced zinc chelate as a new and effective source of zinc in poultry diets.

Indexed as

AntioxidantsChickensDigestionImmunity, InnateZincAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsBiological AvailabilityDietDietary SupplementsDose-Response Relationship, DrugGlycineMaleMethionineOrganometallic CompoundsAntioxidantsGlycineMethionineOrganometallic CompoundsZinczinc methionineZinc SulfateAdvanced zinc chelate supplement, Growth performance, Metabolic indices, ImmunityBroiler chicken

Identifiers

PMID41130047
PMCPMC12581715

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.