Evidence map›Paper›PMID 41130038›Full record

GuidelineThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Guideline for antimicrobial treatment of multidrug-resistant Gram-negative infections: practice recommendations of the Brazilian Society of Infectious Diseases.

Alexandre Prehn Zavascki, Alberto Chebabo, Clovis Arns Cunha, Alexandre Rodrigues Silva, Gabriel Trova Cuba, Daniel Wagner C L Santos, Ana Cristina Gales

Abstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Molecular characterization of extended-spectrum β-lactamases-producing Escherichia coli isolated from patients with bacteremia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandre Prehn ZavasckiDepartamento de Medicina Interna, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Serviço de Doenças Infecciosas, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Hospital Moinhos de Vento, Serviço de Doenças Infecciosas e Controle de Infecções, Porto Alegre, RS, Brazil.
Alberto ChebaboUniversidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil.
Clovis Arns CunhaUniversidade Federal do Paraná, Curitiba, PR, Brazil.
Alexandre Rodrigues SilvaHospital Estadual Doutor Dório Silva, Serra, ES, Brazil.
Gabriel Trova CubaDivisão de Doenças Infecciosas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Daniel Wagner C L SantosDepartamento de Doenças Infecciosas, Universidade Federal do Maranhão, Hospital Universitário Presidente Dutra, São Luís, MA, Brazil; Instituto D'Or de Pesquisa e Ensino, Hospital UDI, Rede D'Or, São Luís, MA, Brazil.
Ana Cristina GalesDivisão de Doenças Infecciosas, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Antimicrobial Resistance Institute of São Paulo (ARIES), São Paulo, SP, Brazil. Electronic address: ana.gales@unifesp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although international guidelines are available, a national consensus is crucial to address the unique challenges faced in Brazil regarding the management of infections caused by multidrug-resistant Gram-negative bacilli (MDR-GNB). These challenges include marked regional disparities in antimicrobial access, variability in pathogen prevalence and resistance patterns, and unequal availability of diagnostic resources. This guideline, developed by a consensus of infectious diseases experts nominated by the Brazilian Society of Infectious Diseases, aims to support clinicians, particularly non-specialists, in the management of MDR-GNB infections across diverse healthcare settings in the country. The document focuses on pathogens classified as critical or high-priority by the World Health Organization (WHO), including Carbapenem-Resistant Enterobacterales (CRE), Acinetobacter baumannii (CRAB), and Pseudomonas aeruginosa (CRPA), ESBL- and AmpC-producing Enterobacterales, as well as Stenotrophomonas maltophilia, and Burkholderia cepacia. Therapeutic recommendations are organized by pathogen and infection site, including respiratory tract, skin and soft tissue, bloodstream, intra-abdominal, and both complicated and uncomplicated urinary tract infections.

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialGram-Negative BacteriaGram-Negative Bacterial InfectionsBrazilHumansAnti-Bacterial AgentsAcinetobacter baumanniiAntimicrobial resistanceCarbapenemsEnterobacteralesPseudomonas aeruginosaTherapy

Identifiers

PMID41130038
PMCPMC12589972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.