Evidence map›Paper›PMID 41130021›Full record

ArticleMolecular pharmacology2025

Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.

Lenah S Binmahfouz, Mahvash A Goolam, Eleanor Barker, Arthur D Conigrave, Donald T Ward

Abstract read
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In one paragraph

Article in Molecular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lenah S BinmahfouzDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Mahvash A GoolamSchool of Life and Environmental Sciences, Charles Perkins Centre (D17), University of Sydney, New South Wales, Australia.
Eleanor BarkerFaculty of Biology, Medicine and Health, The University of Manchester, United Kingdom.
Arthur D ConigraveSchool of Life and Environmental Sciences, Charles Perkins Centre (D17), University of Sydney, New South Wales, Australia.
Donald T WardFaculty of Biology, Medicine and Health, The University of Manchester, United Kingdom. Electronic address: d.ward@manchester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular calcium-sensing receptors (CaSRs) are required for whole-body calcium homeostasis and operate as homodimers, shown structurally to bind only one heterotrimeric G protein at a time. Whether the intracellular domain (ICD) of the other, uncoupled monomer is functionally redundant or still required for optimal CaSR signaling remains unknown. Cotransfection of human embryonic kidney 293 cells with receptors containing both extracellular (CaSR

Indexed as

Protein MultimerizationReceptors, Calcium-SensingSignal TransductionCalciumHEK293 CellsHumansMutationPhosphorylationProtein DomainsCalciumReceptors, Calcium-SensingCalcium-sensing receptorG protein–coupled receptor trans-activationHomodimeric G protein–coupled receptor signaling

Identifiers

PMID41130021
PMCPMC12799464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.