Evidence map›Paper›PMID 41130020›Full record

ArticleMolecular pharmacology2025

Mice carrying the human dopamine D2 receptor pathogenic mutation p.Met374Arg exhibit hyperactivity and aberrant D2 receptor function.

Dayana Rodriguez-Contreras, Joseph J Lebowitz, Cheryl Reed, Elizabeth Walker-Ziegler, David C Buck, Guochuan Li, Shu Xie, Yulong Li, Lev M Fedorov, Tamara J Phillips and 2 more

Abstract read
In one paragraph

Article in Molecular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dayana Rodriguez-ContrerasResearch Service, VA Portland Health Care System, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon.
Joseph J LebowitzVollum Institute, Oregon Health & Science University, Portland, Oregon.
Cheryl ReedResearch Service, VA Portland Health Care System, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon.
Elizabeth Walker-ZieglerResearch Service, VA Portland Health Care System, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon.
David C BuckResearch Service, VA Portland Health Care System, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon.
Guochuan LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, and PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
Shu XieState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, and PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
Yulong LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, and PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
Lev M FedorovTransgenic Mouse Models Shared Resource, Oregon Health & Science University, Portland, Oregon.
Tamara J PhillipsResearch Service, VA Portland Health Care System, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon.
John T WilliamsVollum Institute, Oregon Health & Science University, Portland, Oregon.
Kim A NeveResearch Service, VA Portland Health Care System, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon. Electronic address: nevek@ohsu.edu.

Funding

Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAMARA J. PHILLIPS · 2006 to 2026
$34.5M
Selective Breeding for Drinking in the Circadian DarkU01AA013519 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Angela Renee Ozburn · 2001 to 2026
$10.9M
THERMAL AND METABOLIC DYSFUNCTION DURING WITHDRAWALP50AA010760 · NIAAA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI CRABBE, JOHN C. · 1996 to 2005
$10.7M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
COCAINE: EFFECTS ON SINGLE NEURONSR01DA004523 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1987 to 2025
$7.6M
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
Genetic Risk for Methamphetamine AbuseU01DA041579 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2016 to 2020
$2.1M
Genetic Factors Underlying Risk for Methamphetamine Intake and Associated TraitsR01DA046081 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2018 to 2022
$1.7M
BLRD VA I01 BX003279BLRD VA I01 BX005986BLRD VA IK6 BX006342NIAAA NIH HHS P50 AA010760NIAAA NIH HHS P60 AA010760NIAAA NIH HHS U01 AA013519NIDA NIH HHS R01 DA004523NIDA NIH HHS R01 DA046081NIDA NIH HHS T32 DA007262NIDA NIH HHS U01 DA041579NINDS NIH HHS U01 NS120824
6 · The paper itself

Abstract

Two human dopamine D2 receptor mutations cause dominant hyperkinetic movement disorders. The phenotype of carriers of the DRD2 variant c.634A>T, p.Ile212Phe (D2-I212F) is less severe than that of carriers of the variant c.1121 T>G, p.Met374Arg (D2-M

Indexed as

HyperkinesisMutationReceptors, Dopamine D2AnimalsDopaminergic NeuronsFemaleGain of Function MutationGene Knock-In TechniquesHumansMaleMiceMice, Inbred C57BLMice, TransgenicDRD2 protein, humanDRD2 protein, mouseReceptors, Dopamine D2Dopamine receptorsMouse modelsMovement disordersNeurotransmitter releaseSulpiride

Identifiers

PMID41130020
PMCPMC13095426

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.