Evidence map›Paper›PMID 41129705›Full record

ArticleJournal of Alzheimer's disease : JAD2025

The longitudinal association between dyslipidemia and cognitive trajectory.

Anna Pink, Janina Krell-Roesch, Jeremy A Syrjanen, Maria Vassilaki, Julie A Fields, Bernhard Iglseder, Elmar Aigner, Walter K Kremers, Clifford R Jack, Susan B Racette and 2 more

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna PinkDepartment of Geriatrics, Paracelsus Medical University, Salzburg, Austria.ORCID 0009-0004-4514-2288
Janina Krell-RoeschDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN, USA.ORCID 0000-0003-4011-9842
Jeremy A SyrjanenDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN, USA.ORCID 0000-0001-5990-8206
Maria VassilakiDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN, USA.ORCID 0000-0001-8328-136X
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic Rochester, Rochester, MN, USA.
Bernhard IglsederDepartment of Geriatrics, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-6132-8670
Elmar AignerFirst Department of Medicine, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0003-0310-0536
Walter K KremersDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic Rochester, Rochester, MN, USA.
Susan B RacetteCollege of Health Solutions, Arizona State University, Phoenix, Arizona, USA.ORCID 0000-0002-6932-1887
Ronald C PetersenDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN, USA.
Yonas E GedaDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
APOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
ROCHESTER EPIDEMIOLOGY PROJECTR01AR030582 · NIAMS · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A · 1986 to 2009
$5.1M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Pathways linking neuropsychiatric symptoms with Alzheimer's disease neuroimaging biomarkers and the outcome of incident Mild Cognitive Impairment/ DementiaR01AG057708 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI GEDA, YONAS E · 2018 to 2022
$1.7M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437k
NIAMS NIH HHS R01 AR030582NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG057708NIA NIH HHS R01 AG069453NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738NIA NIH HHS R37 AG011378NIA NIH HHS U01 AG006786NINDS NIH HHS R01 NS097495
6 · The paper itself

Abstract

BackgroundThe literature on dyslipidemia and cognitive trajectories among cognitively unimpaired (CU) persons remains inconclusive.ObjectiveTo investigate the association between baseline dyslipidemia and change in global and domain specific (i.e., memory, language, attention/executive function, and visuospatial skills) cognition in a population-based setting and whether the association differs by sex, age, or

Indexed as

CognitionCognitive DysfunctionDyslipidemiasAgedAged, 80 and overAgingApolipoprotein E4FemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsApolipoprotein E4Alzheimer's diseasecognitive declinecognitive domainscognitive trajectorydyslipidemia

Identifiers

PMID41129705
PMCPMC12892842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.