Evidence map›Paper›PMID 41129695›Full record

ArticleBiomacromolecules2025

Well-Defined Glycopolymer Chitosan Mimics for Design of Chitosan Nanocomposites.

Toby R Edwards, Penelope E Jankoski, Latoyia P Downs, Musa Rabiu, Lisa K Kemp, Travis L Thornell, Dane N Wedgeworth, J Kent Newman, Tristan D Clemons, Shahid Karim and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toby R EdwardsSchool of Polymer Science and Engineering, University of Southern Mississippi, 118 College Drive, #5050, Hattiesburg, Mississippi 39406, United States.
Penelope E JankoskiSchool of Polymer Science and Engineering, University of Southern Mississippi, 118 College Drive, #5050, Hattiesburg, Mississippi 39406, United States.
Latoyia P DownsSchool of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, 118 College Drive, #5018, Hattiesburg, Mississippi 39180, United States.
Musa RabiuSchool of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, 118 College Drive, #5018, Hattiesburg, Mississippi 39180, United States.
Lisa K KempSchool of Polymer Science and Engineering, University of Southern Mississippi, 118 College Drive, #5050, Hattiesburg, Mississippi 39406, United States.
Travis L ThornellU.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States.
Dane N WedgeworthU.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States.
J Kent NewmanU.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States.
Tristan D ClemonsSchool of Polymer Science and Engineering, University of Southern Mississippi, 118 College Drive, #5050, Hattiesburg, Mississippi 39406, United States.ORCID 0000-0001-8042-0141
Shahid KarimSchool of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, 118 College Drive, #5018, Hattiesburg, Mississippi 39180, United States.
Sarah E MorganORCID 0000-0002-8796-9548

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
PLURIPOTENCY OF NOVEL TICK CYSTEINE PROTEASE INHIBITORS DURING HEMATOPHAGYR15AI167013 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MORGAN, SARAH E · 2022 to 2022
$444k
Supramolecular polymers for targeted protein degradationR03EB033704 · NIBIB · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI CLEMONS, TRISTAN · 2022 to 2023
$148k
NIAID NIH HHS R15 AI167013NIBIB NIH HHS R03 EB033704NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Chitosan, a naturally derived polysaccharide with intriguing antimicrobial and polycationic properties, is highly desirable as a biosourced and biodegradable material for biomedical, food packaging, and personal care applications. Its inherent high levels of variability in molecular weight, dispersity, and degree of deacetylation, however, make the establishment of structure-property-processing relationships difficult and limit materials development. In this study, a novel methacrylate-based glycomonomer with saccharide structure similar to that of chitosan was synthesized and copolymerized with methyl methacrylate via reversible addition-fragmentation chain-transfer (RAFT) polymerization to create a series of well-defined chitosan mimics with controlled molecular weights and low dispersity (<1.1). Evaluation of mammalian cytotoxicity and antibacterial activity against

Indexed as

Anti-Bacterial AgentsChitosanNanocompositesAnimalsEscherichia coliGraphiteHumansMiceMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsChitosangraphene oxideGraphite

Identifiers

PMID41129695
PMCPMC12606564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.