ArticleJournal of magnetic resonance imaging : JMRI2026
Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Long-Term Follow-Up of Deformations and Hemodynamics.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Long-Term Follow-Up of Deformations and Hemodynamics.Journal of magnetic resonance imaging : JMRI · 2026Article
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6 authors.
Funding
Abstract
backgroundA detailed evaluation of hemodynamics, supportive morphology, and deformation may help uncover the pathophysiology of hypertrophic obstructive cardiomyopathy (HOCM) and the changes wrought by alcohol septal ablation (ASA). PURPOSE: To investigate the global cardiac volume, myocardial deformation, and hemodynamic characteristics before and during long-term follow-up after ASA in patients with HOCM. STUDY TYPE: Retrospective. SUBJECTS: Twenty-three patients (68.1 ± 8.6 years, 21.7% male) with HOCM who underwent MRI before and after ASA. FIELD STRENGTH/SEQUENCE: A 3T, Two-dimensional fast imaging employing steady-state acquisition, inversion recovery-prepared fast gradient echo sequences, and cine and time-resolved three-dimensional cine phase-contrast (4D flow) MRI. ASSESSMENT: Global left ventricular (LV) volume by cine, peak strain, and strain rate by myocardial feature-tracking MRI, and hemodynamic characteristics by 4D flow MRI. STATISTICAL TESTS: Paired t-test and Wilcoxon signed-rank test compared normally and nonnormally distributed data, respectively. Chi-squared or Fisher's exact tests were used to compare categorical data, as appropriate. Pearson's or Spearman's correlation coefficient evaluated the correlations. Statistical significance was set at q ≤ 0.10 or p < 0.05.
resultsIn LV long-axis images, the global radial strain increased significantly (16.6% ± 5.8% vs. 20.1% ± 6.8%), whereas the global longitudinal strain decreased significantly after ASA (-10.5% ± 3.2% vs. -12.1% ± 3.5%). The diastolic LV anterior vortex area increased significantly after ASA (2256.1 [703.6, 4038.4] vs. 3826.1 [1914.3, 4820.1] mm DATA
conclusionsFeature-tracking and 4D flow MRI revealed improved systolic and diastolic LV function during long-term follow-up after ASA. The diastolic LV vortex was associated with the combined parameters of LV volume and deformation. Comprehensive cardiac MRI may help understand the beneficial effects of ASA. EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 5.
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