Evidence map›Paper›PMID 41129511›Full record

ReviewPLoS pathogens2025

Microbial links to Alzheimer's disease.

Courtney P Cornitius, Emily K Perez, Soo Chan Lee

Abstract readReview
In one paragraph

Review in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Courtney P CornitiusSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas, United States of America.
Emily K PerezSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas, United States of America.
Soo Chan LeeSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas, United States of America.ORCID 0000-0002-7792-5947

Funding

A novel link between calcineurin, amino acid permease, and protein kinase A in virulence in MucorR01AI182221 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Soo Chan Lee · 2025 to 2026
$1.1M
NIAID NIH HHS R01 AI182221
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a common chronic neurodegenerative disease that is characterized by (1) plaques, (2) neuronal death, (3) hyperphosphorylation of tau proteins, and (4) memory deficits. Despite extensive research, the underlying cause of AD is not fully understood. Evidence that infectious pathogens may trigger AD has been documented for decades. There are notable correlations between microbes (including bacteria, viruses, and fungi) and AD pathologies. Although it is yet to be determined if pathogenic microbes are the causative agent or a contributing factor to AD, the role of infections in the pathogenesis of AD should not be ignored. Even though the pathogens may not cause AD, they may play a direct role in the triggering or exacerbation of AD progression. In this mini review, the current status of pathogens' role in AD etiology will be presented.

Indexed as

Alzheimer DiseaseAnimalsHumans

Identifiers

PMID41129511
PMCPMC12548886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.