Evidence map›Paper›PMID 41129319›Full record

ArticleCell reports2025

Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration.

Jarish N Cohen, Gayatri Kolluri, Sean Clancy, Victoire Gouirand, Courtney E Macon, Lokesh A Kalekar, Michael D Rosenblum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Regulatory T cells: From Foxp3 to tolerance-inducing therapies.The Journal of investigative dermatology · 2026
    Review
  2. Review
  3. Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jarish N CohenDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Gayatri KolluriDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Sean ClancyDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Victoire GouirandDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Courtney E MaconDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Lokesh A KalekarVertex Pharmaceuticals, Boston, MA, USA.
Michael D RosenblumDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: michael.rosenblum@ucsf.edu.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Restoring Immune Balance in Hiddradenitis SuppurativaR01AR075864 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2020 to 2024
$3.5M
Elucidating the Role of Regulatory T cells in Establishing and Maintaining a Th2 Niche in SkinR01AR077553 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2020 to 2024
$3.5M
Elucidating the Cellular and Molecular Mechanisms of How Regulatory T cells in Skin Regulate Fibroblast Activation and Tissue FibrosisR01AR071944 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2018 to 2022
$1.7M
Elucidating the Role of Regulatory T cells in Protecting Epithelial Stem Cell NichesK08AR079596 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jarish Newman Cohen · 2022 to 2026
$882k
BD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573k
NIAMS NIH HHS K08 AR079596NIAMS NIH HHS R01 AR071944NIAMS NIH HHS R01 AR075864NIAMS NIH HHS R01 AR077553NIDDK NIH HHS P30 DK063720NIH HHS S10 OD021822
6 · The paper itself

Abstract

Regulatory T cells (Tregs) play important immunosuppressive and tissue-regenerative functions in skin. A subset of Tregs localizes to hair follicles (HFs), where they promote hair growth through activation of HF stem cells. However, the mechanisms driving Treg accumulation in HFs remain to be identified. We find that Tregs utilize Cxcr4 to accumulate in HF epithelium and that its expression is partially dependent on glucocorticoid receptor signaling. Additionally, we show that Cxcl12, the main cognate ligand of Cxcr4, is enriched in keratinocytes of the upper HF and that disruption of the Cxcr4-Cxcl12 axis results in suboptimal hair growth. Finally, we demonstrate that upper HF keratinocytes in human skin express Cxcr4 ligands in a pattern similar to that in murine skin. Collectively, these results reveal an evolutionary conserved pathway of Treg trafficking within a barrier tissue that promotes hair regeneration, which may have implications for immunotherapeutic modulation of human alopecia.

Indexed as

Chemokine CXCL12Hair FollicleReceptors, CXCR4RegenerationSkinT-Lymphocytes, RegulatoryAnimalsHumansKeratinocytesMiceMice, Inbred C57BLReceptors, GlucocorticoidSignal TransductionChemokine CXCL12Receptors, CXCR4Receptors, GlucocorticoidCP: ImmunologyCP: Stem cell researchCxcl12Cxcr4glucocorticoid receptorhairkeratinocyteskinstem celltissue regenerationTregs

Identifiers

PMID41129319
PMCPMC12871648

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.