Evidence map›Paper›PMID 41129318›Full record

ArticleCell reports2025

Muscle spindles provide flexible sensory feedback for movement sequences.

William P Olson, Varun B Chokshi, Jeong Jun Kim, Noah J Cowan, Daniel H O'Connor

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

William P OlsonThe Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Varun B ChokshiThe Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Jeong Jun KimThe Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Noah J CowanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Daniel H O'ConnorThe Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: dan.oconnor@jhmi.edu.

Funding

Top-down and bottom-up signals for flexible orofacial behaviorsU19NS137920 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Kleinfeld · 2024 to 2026
$15.9M
Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Next-Generation Tools to Measure and Manipulate Muscle Activity Across Species and BehaviorsR01NS109237 · NINDS · EMORY UNIVERSITY · PI Muhannad Bakir, Samuel Sober · 2019 to 2026
$3.8M
Center for Advanced Muscle BioElectronics (CAMBER)U24NS126936 · NINDS · EMORY UNIVERSITY · PI Samuel Sober · 2023 to 2026
$3.5M
Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescalesRF1NS131984 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2023 to 2023
$2.3M
Proprioceptive Coding of Jaw Movement during Orofacial BehaviorF32MH120873 · NIMH · JOHNS HOPKINS UNIVERSITY · PI OLSON, WILLIAM PAUL · 2019 to 2022
$244k
NIMH NIH HHS F32 MH120873NINDS NIH HHS R01 NS104834NINDS NIH HHS R01 NS109237NINDS NIH HHS RF1 NS131984NINDS NIH HHS U19 NS137920NINDS NIH HHS U24 NS126936
6 · The paper itself

Abstract

Sensory feedback is essential for motor performance and must adapt to task demands. Muscle spindle afferents (MSAs) are a major primary source of feedback about movement. Their responses are readily modulated online by fusimotor neurons and, in the unique case of jaw MSAs whose cell bodies lie within the central nervous system, by central synaptic inputs. They are, therefore, a powerful site for implementing flexible sensorimotor control. We record from MSAs innervating the jaw musculature of mice performing a directed lick sequence task. Jaw MSAs encode complex jaw-tongue kinematics. However, kinematic encoding alone accounts for less than half of jaw MSA spiking variability. Jaw MSA coding of kinematics changes based on sequence progression (beginning, middle, or end of the sequence or reward consumption), suggesting that jaw MSAs are flexibly tuned across the task. Dynamic modulation of feedback signals from jaw MSAs may shape sensorimotor control during complex behavior.

Indexed as

Feedback, SensoryMuscle SpindlesAnimalsBiomechanical PhenomenaJawMaleMiceMice, Inbred C57BLMovementTongueCP: Neurosciencejawmovement sequencesmuscle spindle afferentsorofacial behaviorproprioceptionsensorimotor controltongue

Identifiers

PMID41129318
PMCPMC12838438

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.