Evidence map›Paper›PMID 41129280›Full record

ArticleThe FEBS journal2026

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome.

Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider

Abstract read
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In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Corinne von KänelDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland.
Salome AeschlimannDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland.
Michaela HusováFaculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
Silke OeljeklausFaculty of Chemistry and Pharmacy, Biochemistry II, Theodor Boveri-Institute, University of Würzburg, Germany.
Philip StettlerDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland.
Achim SchnauferInstitute of Immunology and Infection Research, University of Edinburgh, UK.
Bettina WarscheidFaculty of Chemistry and Pharmacy, Biochemistry II, Theodor Boveri-Institute, University of Würzburg, Germany.
Alena ZíkováFaculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
André SchneiderDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland.ORCID 0000-0001-5421-0909

Funding

Deutsche Forschungsgemeinschaft SPP2453 Project ID 541758684European Research Council MitoSignal project 101044951European Union CZ.02.01.01/00/22_008/0004575NCCR RNA & Disease 205601Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung SNF 205200
6 · The paper itself

Abstract

Protein import across the mitochondrial inner membrane typically depends on two protein translocases of the inner membrane (TIM) complexes and the membrane potential. The protozoan parasite Trypanosoma brucei, however, has a single, divergent TIM complex. Unlike other trypanosomal TIM subunits, TbTim20 is not essential for the normal growth of the insect or bloodstream forms of T. brucei, leaving its role uncertain. Specific mutations in the γ-subunit of the F

Indexed as

Genome, MitochondrialMembrane Potential, MitochondrialProton-Translocating ATPasesProtozoan ProteinsTrypanosoma brucei bruceiDNA, KinetoplastMitochondriaProtein TransportRNA InterferenceDNA, KinetoplastProton-Translocating ATPasesProtozoan Proteinskinetoplast DNAmitochondrial membrane potentialmitochondrial protein importTIM complexTrypanosoma brucei

Identifiers

PMID41129280
PMCPMC12998175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.