Evidence map›Paper›PMID 41129263›Full record

ArticleThe Journal of clinical investigation2025

Distinct human small intestinal microbiome communities underlie visceral hypersensitivity in a humanized mouse model.

Isin Y Comba, Tijs Louwies, Ruben At Mars, Yang Xiao, Prabhjot Kaur Sekhon, Brian S Edwards, Adam Willits, Robin R Shields-Cutler, Shreya Bellampalli, Arnaldo Mercado-Perez and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Isin Y CombaMayo Clinic, Rochester, Minnesota, USA.
Tijs LouwiesMayo Clinic, Rochester, Minnesota, USA.
Ruben At MarsMayo Clinic, Rochester, Minnesota, USA.
Yang XiaoMayo Clinic, Rochester, Minnesota, USA.
Prabhjot Kaur SekhonMayo Clinic, Rochester, Minnesota, USA.
Brian S EdwardsMayo Clinic, Rochester, Minnesota, USA.
Adam WillitsMayo Clinic, Rochester, Minnesota, USA.
Robin R Shields-CutlerMacalester College, St. Paul, Minnesota, USA.
Shreya BellampalliMayo Clinic, Rochester, Minnesota, USA.
Arnaldo Mercado-PerezMayo Clinic, Rochester, Minnesota, USA.
Dennis R TienterMayo Clinic, Rochester, Minnesota, USA.
Lisa M TillMayo Clinic, Rochester, Minnesota, USA.
David R LindenMayo Clinic, Rochester, Minnesota, USA.
Gianrico FarrugiaMayo Clinic, Rochester, Minnesota, USA.
Arthur BeyderMayo Clinic, Rochester, Minnesota, USA.
Kristen M Smith-EdwardsMayo Clinic, Rochester, Minnesota, USA.
Purna C KashyapMayo Clinic, Rochester, Minnesota, USA.

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI MARK A. MC NIVEN · 2009 to 2026
$22.2M
Mechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7M
MECHANISMS OF VISCERAL PAIN DRIVEN BY SMALL INTESTINAL MICROBIOTAR01DK138818 · NIDDK · MAYO CLINIC ROCHESTER · PI Arthur Beyder, Purna C Kashyap · 2023 to 2026
$3.9M
Mechanisms of osmosensing in GI enteroendocrine cellsF30DK138638 · NIDDK · MAYO CLINIC ROCHESTER · PI Shreya Bellampalli · 2024 to 2026
$149k
NIDDK NIH HHS F30 DK138638NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK114007NIDDK NIH HHS R01 DK138818
6 · The paper itself

Abstract

Specific small-intestinal bacteria, particularly Enterobacteriaceae, can trigger abdominal pain by activating gut sensory and nerve cells, revealing how microbiota contribute to gastrointestinal symptoms.

Indexed as

Abdominal PainEnterobacteriaceaeGastrointestinal MicrobiomeIntestine, SmallAnimalsDisease Models, AnimalHumansMiceBacterial infectionsGastroenterologyMicrobiologyMouse modelsPain

Identifiers

PMID41129263
PMCPMC12700534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.