Evidence map›Paper›PMID 41129243›Full record

ArticleBiochemistry2025

Copper Activates a Redox Switch to Reversibly Inhibit Glyceraldehyde-3-Phosphate Dehydrogenase.

Taylor C Outlaw, Amy T R Robison, Natalie B Schulte, Francesca A Vaccaro, Isabella G Williams, Swara Repala, Diego Diaz, Grace R Sturrock, Michael C Fitzgerald, Katherine J Franz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taylor C OutlawDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.
Amy T R RobisonDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.
Natalie B SchulteDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.ORCID 0000-0003-4274-4289
Francesca A VaccaroDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.ORCID 0000-0002-1167-6108
Isabella G WilliamsDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.
Swara RepalaDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.
Diego DiazDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.
Grace R SturrockDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.
Michael C FitzgeraldDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.ORCID 0000-0002-6719-4722
Katherine J FranzDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States of America.ORCID 0000-0002-9015-0998

Funding

Elucidating the Molecular Basis of Cellular Metal Stress by using Mass Spectrometry-Based Proteomic MethodsR01GM145035 · NIGMS · DUKE UNIVERSITY · PI FITZGERALD, MICHAEL C, FRANZ, KATHERINE J. · 2022 to 2025
$2.1M
NIGMS NIH HHS R01 GM145035
6 · The paper itself

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), one of the most conserved proteins across all kingdoms of life, has a multitude of moonlighting functions beyond its enzymatic role in glycolysis. Metal binding to GAPDH has previously been reported to inhibit enzymatic activity in several prokaryotic and eukaryotic systems, although the mechanism of inhibition has not been elucidated. In this study, we examined the effects of zinc, silver, and copper ions on

Indexed as

CopperEscherichia coliEscherichia coli ProteinsGlyceraldehyde-3-Phosphate DehydrogenasesOxidation-ReductionSilverZincCopperEscherichia coli ProteinsGlyceraldehyde-3-Phosphate DehydrogenasesSilverZinc

Identifiers

PMID41129243
PMCPMC13003450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.