Evidence map›Paper›PMID 41129228›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Exceptional diversity of allorecognition receptors in a nonvertebrate chordate reveals principles of innate allelic discrimination.

Henry Rodriguez-Valbuena, Jorge Salcedo, Olivier De Thier, Jean Francois Flot, Stefano Tiozzo, Anthony W De Tomaso

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henry Rodriguez-ValbuenaDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.ORCID 0000-0002-2687-0333
Jorge SalcedoDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
Olivier De ThierDepartment of Evolutionary Biology and Ecology, Université libre de Bruxelles, Brussels B-1050, Belgium.ORCID 0009-0005-5845-6187
Jean Francois FlotDepartment of Evolutionary Biology and Ecology, Université libre de Bruxelles, Brussels B-1050, Belgium.ORCID 0000-0003-4091-7916
Stefano TiozzoCNRS, Laboratoire de Biologie du Développement de Villefranche Sur-mer, Villefranche Sur-mer 06230, France.
Anthony W De TomasoDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.ORCID 0000-0001-9689-7673

Funding

Allorecognition, parasitic stem cells and regeneration in a basal chordateR35GM139649 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI DE TOMASO, ANTHONY W · 2021 to 2025
$2.4M
Developing a new chordate model for stem cell biology and regenerationR21OD030520 · OD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI DE TOMASO, ANTHONY W · 2022 to 2023
$406k
French National Research Agency ANR-14-CE02-001-01HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM139649HHS | NIH | NIH Office of the Director (OD) OD030520INSB-DBM Evochore INS-DBM EvochoreNCIPC CDC HHS U17 CE002001NIGMS NIH HHS R35 GM139649NIH HHS R21 OD030520
6 · The paper itself

Abstract

Highly polymorphic allorecognition systems have been characterized in numerous invertebrate species, and exhibit discriminatory capabilities reminiscent of vertebrate adaptive immunity. As these systems utilize germline encoded receptors, the mechanisms underlying allelic discrimination are unknown. The invertebrate chordate,

Indexed as

AllelesChordataImmunity, InnateAnimalsallorecognitionevolution immunityimmunogeneticsinnate immunitystructural immunology

Identifiers

PMID41129228
PMCPMC12582321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.