ArticleProceedings of the National Academy of Sciences of the United States of America2025
Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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Who cites it
8 citing papers in PubMed.
- Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.Cancer research communications · 2026Article
- Blockade of Tumor-Intrinsic TGFβ Signaling Drives Hyperprogression in Small Cell Lung Cancer.Cancer discovery · 2026Article
- Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes.bioRxiv : the preprint server for biology · 2026Article
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons.Aging cell · 2026Article
- Stiffness-dependent alveolar type II cell senescence in idiopathic pulmonary fibrosis.Cell communication and signaling : CCS · 2026Article
- The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026Review
- Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
- Update of
Authors and funding
36 authors.
Christopher W SchultzDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-5731-2847
Sourav SahaDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-0854-5991
Anjali DhallDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Yang ZhangDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-7833-1817
Parth DesaiDepartment of Hematology & Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.ORCID 0000-0002-7715-4919
Lorinc S PongorDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
David A ScheiblinOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701.ORCID 0000-0002-5505-2540
Valentin MagidsonOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701.
Ravi P ShuklahDepartment of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.ORCID 0000-0001-7492-5848
Robin SebastianDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Umeshkumar M VekariyaFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.ORCID 0000-0002-6662-9122
Shahbaz AhmedDepartment of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.ORCID 0009-0004-2337-7561
Yilun SunDepartment of Pharmacology, Physiology, and Drug Development, University of Maryland School of Medicine, Baltimore, MD 21201.
Christophe RedonDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Suresh KumarDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-7404-8259
Manan KrishnamurthyDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-8906-0533
Henrique B DiasCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Vasilisa AksenovaDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892.
Elizabeth GiordanoDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892.
Nobuyuki TakahashiDepartment of Medical Oncology, National Cancer Center Hospital East, Kashiwa 277-8577, Japan.ORCID 0000-0002-8592-6528
Michael NirulaDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Mohit AroraDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Chiori TabeDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Maria Sebastian ThomasDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Rajesh KumarDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Yasuhiro ArakawaDepartment of Clinical Pharmacology and Therapeutics, Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0003-1582-0282
Ukhyun JoDevelopmental Therapeutics Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Tomasz SkorskiFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.ORCID 0000-0002-3809-4538
Beverly A TeicherDivision of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD 20892.ORCID 0000-0003-1535-7304
Roshan ShreshtaDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-7597-9418
Mirit I AladjemDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-1875-3110
Stephen LockettOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701.ORCID 0000-0002-2010-9914
Mary DassoDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892.ORCID 0000-0002-5410-1371
Yves PommierDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Ajit K SharmaDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Anish ThomasDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-3293-3115
Funding
Exploiting DNA Replicative Stress for Novel Small Cell Lung Cancer TherapiesZIABC011793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI THOMAS, ANISH · 2018 to 2025
$16.4MUnderstanding and targeting unique vulnerabilities governing G1/S transition and replication stress in small cell lung cancerR00CA277246 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI Christopher William Schultz · 2025 to 2026
$482kHHS | NIH | National Cancer Institute (NCI) R00CA277246HHS | NIH | National Cancer Institute (NCI) ZIA BC 011793Intramural NIH HHS ZIA BC011793NCI NIH HHS R00 CA277246
Abstract
Lamin A/C (
Indexed as
Genomic InstabilityLamin Type ALung NeoplasmsSmall Cell Lung CarcinomaCell Line, TumorDNA ReplicationHumansLamin Type ALMNA protein, humanagingcancerreplication stressR-loopssmall-cell lung cancer (SCLC)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.