Evidence map›Paper›PMID 41129197›Full record

ArticleEndocrinology, diabetes & metabolism2025

Diabetes and Obesity Modify the Effect of Alcohol Consumption on Carbohydrate-Deficient Transferrin.

Tomás González-Vidal, Óscar Lado-Baleato, Fátima de la Osa, Manuela Alonso-Sampedro, Carmen Fernández-Merino, Juan Sánchez-Castro, Francisco Gude, Arturo González-Quintela

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In one paragraph

Article in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomás González-VidalDepartment of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Oviedo, Spain.ORCID https://orcid.org/0009-0006-9147-1757
Óscar Lado-BaleatoResearch Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS-ISCIII), Santiago de Compostela, Spain.
Fátima de la OsaDepartment of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Manuela Alonso-SampedroResearch Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS-ISCIII), Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0002-0916-4672
Carmen Fernández-MerinoResearch Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS-ISCIII), Santiago de Compostela, Spain.
Juan Sánchez-CastroResearch Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS-ISCIII), Santiago de Compostela, Spain.
Francisco GudeResearch Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS-ISCIII), Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0002-9681-1662
Arturo González-QuintelaResearch Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS-ISCIII), Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0002-6909-1807

Funding

European UnionGalician Innovation Agency-Competitive Benchmark Groups GAIN-GRC/IN607A/2021/02/Xunta de GaliciaInstituto de Salud Carlos III CM24/00080Instituto de Salud Carlos III ISCIII/PT23/00118Instituto de Salud Carlos III PI20/01069Instituto de Salud Carlos III RD21/0016/0022
6 · The paper itself

Abstract

aimsSerum levels of carbohydrate-deficient transferrin (CDT, the sum of its asialylated and disialylated glycoforms) are a commercial marker of alcohol abuse. Our aim was to investigate the potential influence of metabolic factors on serum CDT levels and the predictive value of transferrin glycoforms for the development of type 2 diabetes in a general adult population. MATERIALS AND

methodsWe measured serum CDT levels by capillary electrophoresis in 1516 individuals (median age 52 years; 55.3% women) randomly selected from the general adult population of a municipality.

resultsInsulin resistance and the associated body mass index and diabetes modified the effect of alcohol consumption on CDT levels; i.e., CDT in heavy drinkers was lower in individuals with obesity than in lean counterparts and was also lower in people with diabetes than in normoglycaemic individuals. The relative abundance of transferrin glycoforms was not significantly associated with the development of type 2 diabetes after a mean follow-up of 7.4 years.

conclusionsThere is an interaction between alcohol consumption and factors associated with insulin resistance in relation to transferrin sialylation. The sensitivity of CDT for detecting heavy alcohol consumption might be limited in people with obesity or diabetes.

Indexed as

Alcohol DrinkingDiabetes Mellitus, Type 2ObesityTransferrinAdultAgedBiomarkersBody Mass IndexFemaleHumansInsulin ResistanceMaleMiddle AgedBiomarkerscarbohydrate-deficient transferrinTransferrinalcoholcarbohydrate‐deficient transferrindiabetesinsulin resistanceobesitysialylation

Identifiers

PMID41129197
PMCPMC12548559

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.