Evidence map›Paper›PMID 41129196›Full record

ArticleACS biomaterials science & engineering2025

Effects of Stiffness and Degradability on Cardiac Fibroblast Contractility and Extracellular Matrix Secretion in Three-Dimensional Hydrogel Scaffolds.

Kathleen N Halwachs, Alexander Hillsley, Alex Khang, Logan D Morton, Michael S Sacks, Janet Zoldan, Adrianne M Rosales

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathleen N HalwachsMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-3319-8450
Alexander HillsleyMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-7920-2104
Alex KhangDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Logan D MortonMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-0767-9709
Michael S SacksDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Janet ZoldanDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-7089-7683
Adrianne M RosalesMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-0207-7661

Funding

Dynamic ECM-Mimicking Biomaterials for Ischemia TreatmentR01HL157829 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI ZOLDAN, JANETA · 2022 to 2025
$2.3M
Expanding the Functionality of Engineered Extracellular MatricesR35GM138193 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ROSALES, ADRIANNE · 2020 to 2024
$1.9M
Identifying the role of aortic valve interstitial cells and altered micro-environment on bicuspid aortic valve disease progression.F31HL154654 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI KHANG, ALEX · 2020 to 2021
$76k
NHLBI NIH HHS F31 HL154654NHLBI NIH HHS R01 HL157829NIGMS NIH HHS R35 GM138193
6 · The paper itself

Abstract

Cardiac fibrosis results from persistent cardiac fibroblast activation and is heavily dependent on the interplay of extracellular matrix mechanics and proinflammatory cytokines. Studying this interplay using

Indexed as

Extracellular MatrixFibroblastsHydrogelsMyocardiumTissue ScaffoldsAnimalsCells, CulturedMyofibroblastsRatsTransforming Growth Factor betaHydrogelsTransforming Growth Factor betacardiac fibroblastcontractilityextracellular matrixhydrogel

Identifiers

PMID41129196
PMCPMC13393519

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.