Evidence map›Paper›PMID 41129042›Full record

ArticleApplied biochemistry and biotechnology2025

Green Synthesis of Silver Nanoparticles Using Cynoglossum creticum Leaf Extract: Eco-Friendly Approach for Antibacterial, Antioxidant, and Sensing Applications.

Seif El Islam Boudagha, Chafia Sobhi, Hamdi Bendif, Emel Öykü Çetin Uyanikgil, Amdjed Abdennouri, Mustafa Ökeer, Chawki Bensouici, Moussa Boudiaf, Ahmed Zouaoui, Hassan A Rudayni and 2 more

Abstract read
In one paragraph

Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seif El Islam BoudaghaLaboratoire de Physico-Chimie Des Surfaces Et Des Interfaces, Université 20 Août 1955 de Skikda, BP 26, Route El Hadaik, Skikda, 21000, Algeria.
Chafia SobhiLaboratory of Materials and Energetic Engineering, Faculty of Technology, University of 20 August 1955, BP 26, Skikda, 21000, Algeria.
Hamdi BendifDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia. hlbendif@imamu.edu.sa.
Emel Öykü Çetin UyanikgilDepartment of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Amdjed AbdennouriLaboratory of Catalysis, Bioprocess and Environment, Department of Process Engineering, Faculty of Technology, University of 20August 1955, Skikda, 21000, Algeria.
Mustafa ÖkeerDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Chawki BensouiciLaboratory of Biochemistry, Biotechnology and Health Division, Center for Research in Biotechnology, Constantine, 25000, Algeria.
Moussa BoudiafLCIMN Laboratory, Department of Process Engineering, Faculty of Technology, University Ferhat Abbas Setif-1, Sétif, 19000, Algeria.
Ahmed ZouaouiLaboratoire Croissance Et Caractérisation de Nouveaux Semiconducteurs (LCCNS), Université Ferhat Abbas Sétif-1, Sétif, Algeria.
Hassan A RudayniDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
Fehmi BoufahjaDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
Stefanıa GarzoliDepartment of Chemistry and Technologies of Drug, Sapienza University, Rome, 00185, Italy. stefania.garzoli@uniroma1.it.

Funding

Deanship of Scientific Research, King Khalid University IMSIU-DDRSP2501
6 · The paper itself

Abstract

Nanotechnology leveraging renewable plant biomass to develop silver nanoparticles offers eco-friendly solutions with more sustainable applications. The present research explores the employment of an aqueous extract of Cynoglossum creticum leaves in the green synthesis of silver nanoparticles (Ccl-AgNPs) for potential biological and sensing purposes. The synthesis parameters were controlled spectrophotometrically, and the physicochemical characterizations of Ccl-AgNPs were evaluated. Phytochemicals in the extract served dual roles, as confirmed by infrared spectroscopy analysis. Thermogravimetric analysis (TGA) and energy-dispersive X-ray spectroscopy (EDS) further revealed the presence of a plant-derived organic matter on AgNPs. Morphological descriptions indicated the spherical form of Ccl-AgNPs, comprising a median size of 32 nm. Furthermore, the biological characteristics of green Ccl-AgNPs were investigated, as they showed promising antioxidant activities in DPPH, ABTS, reducing power, and phenanthroline assays. Ccl-AgNPs also exhibited a good inhibitory impact on the growth of four tested Gram-positive and Gram-negative bacteria. Pseudomonas aeruginosa was most susceptible to the inhibitory activity of Ccl-AgNPs, with a minimum inhibitory dose of 31.25 µg/mL. Colloidal AgNPs capped by Ccl-extract have established the potential for use as an SPR-based colorimetric sensing system for the selective detection of neomycin sulfate, with a limit of detection (LOD) of 2.88 µM. The colorimetric probe was successfully tested for neomycin sulfate detection in environmental and biological fluids and veterinary pharmaceutical preparations, with recovery rates ranging between 92.62 and 105.76%. This study underscores the potential of Cynoglossum creticum, a livestock-hazardous weed, as a sustainable resource for synthesizing silver nanoparticles for potential ecological and biomedical uses.

Indexed as

Anti-Bacterial AgentsAntioxidantsGreen Chemistry TechnologyMetal NanoparticlesPlant ExtractsPlant LeavesSilverAnti-Bacterial AgentsAntioxidantsPlant ExtractsSilverAntibacterialAntioxidantColorimetric sensingCynoglossum creticumSilver nanoparticles

Identifiers

PMID41129042
PMCPMC12718234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.