ArticleImmunologic research2025
Saccharin from sweetener to immune orchestrator: Saccharin-induced neutrophil chemotaxis and transmigration via taste receptor signaling.
Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Heterogeneous Biological Responses to Low-Level Sodium Saccharin Exposure: An Integrated Computational Toxicology and Mendelian Randomization Study.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular immune response is not only affected by endogenous cytokines or mediators but also affected by exogenous chemical products from food. Human blood leukocytes express members of chemosensory taste receptors such as sweet and umami taste receptors (TAS1Rs) and bitter taste receptors (TAS2Rs). These ectopic taste receptors have been found to sense irritants or bacterial lipopolysaccharides and activate innate immunity. Saccharin, an artificial sweetener, can modulate the cellular immune response via the leukocytic taste receptors. The study aimed to investigate the in vitro effect of saccharin on the function of isolated polymorphonuclear neutrophils (PMNs) in the blood by stimulating sweet taste receptors. Chemotaxis and transmigration assays were measured along with transcriptional profiling of selected neutrophil inflammatory chemokines (CXCL1, CCL2 and CCL26) and chemokine receptors (IL8R and CCR4) following in vitro stimulation by saccharin through siRNA knockdown and RT-qPCR. Saccharin was found to activate chemotaxis in isolated human leukocytes and also to activate PMN migration in a concentration-dependent manner. It was found that siRNA against TAS1R2 or TAS1R3 suppressed PMN migration towards saccharin. On the other hand, no loss of migration occurred in PMN transfected with siRNA against TAS1R1 or in non-siRNA transfected PMNs. Incubation of PMNs with saccharin resulted in a significant upregulation of chemokine and chemokine receptor transcript levels. Our study indicates that saccharin can orchestrate innate immunity by stimulating their cognate taste receptors in the peripheral blood PMNs by signaling chemokines and their receptors.
Indexed as
Identifiers
41129033What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.