Evidence map›Paper›PMID 41129030›Full record

ReviewCurrent cardiology reports2025

Left Atrial Coupling Index for the Prediction of Atrial Fibrillation and Heart Failure: Current Evidence and Clinical Implications.

Tea Gegenava, Stephan Milhorini Pio, Koen Nieman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tea GegenavaDepartment of Internal Medicine №1, Tbilisi State Medical University, Tbilisi, Georgia.
Stephan Milhorini PioDepartment of Echocardiogram Imaging, Faculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Sao Paulo, Brazil.
Koen NiemanDepartment of Medicine, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA. knieman@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe aim of this review paper is to explore the clinical utility of left atrial coupling indices—LACI-v/m (volumetric/mechanical) and LACI-av (atrioventricular volumetric)—as emerging predictors of atrial fibrillation (AF) and heart failure (HF). It emphasizes their relevance in the context of diastolic dysfunction and left heart remodeling. RECENT

findingsLACI-v/m, calculated by dividing indexed left atrial volume by a′ velocity, has been independently associated with incident AF and HF across diverse populations. LACI-av, defined as the ratio of left atrium (LA) to left ventricular (LV) end-diastolic volumes, is applicable in AF and has demonstrated predictive value for AF, HF, and mortality using echocardiography, cardiac MRI, and CT. A meta-analysis confirmed a significant association between elevated LACI and AF risk. Given the interdependence of LA and LV function, both LACI-v/m and LACI-av enhance cardiovascular risk stratification by integrating left atrial structure and function. Future prospective studies are needed to validate standardized thresholds and guide LACI-based management strategies.

Indexed as

Atrial FibrillationAtrial Function, LeftHeart AtriaHeart FailureAtrial RemodelingEchocardiographyHumansPredictive Value of TestsRisk AssessmentAtrial fibrillationAtrial functionEchocardiographyHeart failureLeft atrial coupling index

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.