Evidence map›Paper›PMID 41128961›Full record

ArticleJournal of autism and developmental disorders2025

Brief Report: Differences Between Stanford-Binet Abbreviated and Full-Scale Estimates of IQ in Fragile X Syndrome Vary Across Development.

Walker S McKinney, Meredith Nelson, Rebecca C Shaffer, Kelli C Dominick, Craig A Erickson, Lauren M Schmitt

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Walker S McKinneyDepartment of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA. wsmckinney@cmh.edu.ORCID http://orcid.org/0000-0001-5281-3749
Meredith NelsonDepartment of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.
Rebecca C ShafferDepartment of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.
Kelli C DominickDivision of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Craig A EricksonDivision of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Lauren M SchmittPhelan-McDermid Syndrome Foundation, Osprey, FL, USA.

Funding

Neurophysiological and acute pharmacological studies in FXS patientsU54HD082008 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI HUBER, KIMBERLY M. · 2014 to 2019
$9.8M
Translational medicine and mechanistic studies of brain neurophysiology in Fragile X SyndromeU54HD104461 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI HUBER, KIMBERLY M. · 2020 to 2024
$8.1M
Electrophysiological Biomarkers of Neurocognitive Deficits in Fragile X SyndromeK23HD101416 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI SCHMITT, LAUREN · 2020 to 2024
$617k
Eunice Kennedy Shriver National Institute of Child Health and Human Development K23HD101416Eunice Kennedy Shriver National Institute of Child Health and Human Development U54HD082008Eunice Kennedy Shriver National Institute of Child Health and Human Development U54HD104461NICHD NIH HHS K23 HD101416NICHD NIH HHS U54 HD082008NICHD NIH HHS U54 HD104461
6 · The paper itself

Abstract

purposeFragile X syndrome (FXS) is the most common inherited cause of intellectual disability and single-gene cause of autism. The Stanford-Binet, Fifth Edition (SB-5) is commonly used to assess IQ in FXS. It is not known if the SB-5 routing form's abbreviated IQ (ABIQ) score accurately estimates full-scale IQ (FSIQ), limiting data-informed decision-making when choosing between an abbreviated or full SB-5 battery.

methods198 participants with FXS (143 males) aged 4 to 47 years of age completed the full SB-5. We calculated differences between abbreviated and full-scale estimates of IQ and assessed the extent to which the agreement between ABIQ and FSIQ varied as a function of age, routing subtest scatter, and FSIQ.

resultsThe abbreviated SB-5 battery over-estimated FSIQ in most school-age children (< 11 years), and under-estimated FSIQ in adolescents and adults. This under-estimate of FSIQ was larger when there was a greater discrepancy (scatter) between the two routing subtests that comprise ABIQ and in individuals with FSIQ < 68.

conclusionClinicians and researchers should consider administering the full SB-5 battery to individuals with FXS when possible. If only an abbreviated estimate of IQ is available, ABIQ should be interpreted with caution based on our findings of over- or under-estimation occurring across development. Large discrepancies between verbal and nonverbal skills as well as greater severity of ID should both serve as cues to administer the full battery to avoid under-estimating cognitive skills that are otherwise only captured by FSIQ.

Indexed as

CognitionFragile X syndromeIntellectual disabilityIntelligenceIQStanford–Binet

Identifiers

PMID41128961
PMCPMC12958467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.