Evidence map›Paper›PMID 41128949›Full record

ReviewCurrent hypertension reports2025

Impact of Adverse Childhood Experiences on Cardiovascular Health across the Lifespan.

Ananya Mukundan, Tammy M Brady

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ananya MukundanJohns Hopkins University, The David M. Rubenstein Child Health Building, 200 N. Wolfe St, Room 3062, Baltimore, MD, 21287, USA.
Tammy M BradyJohns Hopkins University, The David M. Rubenstein Child Health Building, 200 N. Wolfe St, Room 3062, Baltimore, MD, 21287, USA. tbrady8@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPediatric hypertension is an increasingly recognized public health issue and represents a key target for preventing long-term cardiovascular morbidity and mortality. Adverse childhood experiences-traumatic events related to abuse, neglect, and household dysfunction occurring before age 18-are emerging as significant risk factors for both pediatric and adult hypertension and cardiovascular disease (CVD).

findingsWhile some studies report direct links between childhood adversity and cardiovascular outcomes, others suggest these associations may be mediated by the development of intermediate CVD risk factors such as obesity and mood disorders. Regardless of pathway, evidence indicates that even exposure to a single form of adversity can negatively impact cardiovascular health, with some studies demonstrating threshold and cumulative effects. Early identification of children exposed to adversity may offer a valuable opportunity to guide targeted interventions aimed at the primary prevention of CVD.

Indexed as

Adverse Childhood ExperiencesCardiovascular DiseasesHypertensionAdolescentAdultChildHeart Disease Risk FactorsHumansRisk FactorsAdversityCardiovascular diseaseCardiovascular healthPediatricsTrauma

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.