Evidence map›Paper›PMID 41128948›Full record

ReviewCurrent cardiology reports2025

Human iPSC-Based in Vitro Cardiovascular Tissue Models for Drug Screening Applications.

Shivesh Anand, Gaoxian Chen, Astha Khanna, Ngan F Huang

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shivesh Anand *Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, 94305, USA.
Gaoxian Chen *Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, 94305, USA.
Astha Khanna *Graver Technologies, Newark, NJ, 07105, USA.
Ngan F HuangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, 94305, USA. ngantina@stanford.edu.ORCID http://orcid.org/0000-0003-2298-6790

Funding

Development of a Bioengineered Therapeutic Device for the Prevention of LymphedemaR01CA285372 · NCI · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI Ngan F. Huang, Michael Vitoldovich Paukshto · 2024 to 2026
$1.6M
Biomaterials for delivery and maintenance of tip endothelial cellsR21HL172096 · NHLBI · UNIVERSITY OF CALIFORNIA, MERCED · PI HUANG, NGAN F., MCCLOSKEY, KARA E · 2024 to 2025
$643k
Enhance Cell Therapies for Peripheral Arterial Disease Using Human-Compatible Protease-Based ControlsR21HL177570 · NHLBI · STANFORD UNIVERSITY · PI GAO, XIAOJING J, HUANG, NGAN F. · 2025 to 2025
$410k
Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Peripheral Artery DiseaseR41HL170875 · NHLBI · SERINA THERAPEUTICS, INC. · PI HUANG, NGAN F., LEE, JI EUN · 2023 to 2023
$341k
BLRD VA I01 BX004259BLRD VA I01 BX006882BLRD VA IK6 BX006309National Science Foundation 1829534NCI NIH HHS R01 CA285372Netherlands Organisation for Scientific Research 019.243EN.042NHLBI NIH HHS R21 HL172096NHLBI NIH HHS R21 HL177570NHLBI NIH HHS R41 HL170875NIH HHS 1R21HL177570RRD VA I21 RX004898U.S. Department of Veterans Affairs 1I01BX004259
6 · The paper itself

Abstract

purpose of reviewTo provide an overview of human induced pluripotent stem cell (hiPSC)-derived cardiovascular lineages and describe their impact on drug testing in vitro. RECENT

findingshiPSCs have garnered tremendous interest over the last decade due to their potential for unlimited proliferation and differentiation into cardiovascular lineages. Technologies using tissue engineering, 3D bioprinting, and organ-on-a-chip platforms composed of hiPSC derivatives can produce cardiovascular tissue mimetics that enhance drug screening applications. hiPSC-derived cardiovascular lineages advance drug screening efforts by using autologous cells that are more therapeutically relevant. Established approaches to reproducibly generate hiPSC-derived cardiovascular lineages and their subsequent organization into 3D constructs more accurately mimic the physiological organization of cardiac tissue, leading to improved identification of potential drug targets for therapeutic testing.

Indexed as

Induced Pluripotent Stem CellsMyocytes, CardiacTissue EngineeringCell DifferentiationDrug Evaluation, PreclinicalHumansCardiovascularDrug screeningInduced pluripotent stem cellOrgan-on-a-chipTissue engineering

Identifiers

PMID41128948
PMCPMC12971102

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.