Evidence map›Paper›PMID 41128888›Full record

ArticleCancer immunology, immunotherapy : CII2025

Assessment of tertiary lymphoid structures via

Yu Yan, Xuan Zou, Xuan Lin, Xu Wang, Yusheng Chen, Mingjian Ma, Xu Wang, Mengxing Pan, Xianjun Yu, Chen Liu and 1 more

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. A simple MRI/PET-derived index predicts relapse-free survival after neoadjuvant chemoradiotherapy in locally advanced rectal cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu Yan *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xuan Zou *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xuan Lin *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xu WangDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Yusheng ChenDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Mingjian MaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xu WangDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Mengxing PanDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xianjun YuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. yuxianjun@fudanpci.org.
Chen LiuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. liuchen@fudanpci.org.
He ChengDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. chenghe@fudanpci.org.

Funding

Clinical and Scientific Innovation Project of Shanghai Hospital Development Center SHDC12018109Clinical Research Plan of Shanghai Hospital Development Center SHDC2020CR1006ANational Key Research and Development Program of China 2020YFA0803202, 2022YFC280480Natural Science Foundation of Shanghai 18ZR1404500, 23ZR1412100Shanghai Municipal Science and Technology Major Project 21JC1401500the National Natural Science Foundation of China 82072693, 81902417, 82172884, U21A20374, 82472954The Scientific Innovation Project of Shanghai Education Committee 2019-01-07-00-07-E00057Young Scientist Project of National Key Research and Development Program of China 2022YFC2804800
6 · The paper itself

Abstract

Pancreatic adenocarcinoma (PAAD) is one of the most malignancies with a poor prognosis. The immune phenotype of pancreatic cancer is remarkably complex, presenting a significant challenge to the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) are active zones composed of various immune cells, which reflect immune responses against cancer. TLSs have emerged as critical biomarkers for predicting immunotherapy outcomes, potentially reflecting alterations in the metabolic characteristics of the host. Accumulating evidence indicates that

Indexed as

AdenocarcinomaFluorodeoxyglucose F18Pancreatic NeoplasmsPositron Emission Tomography Computed TomographyTertiary Lymphoid StructuresAdultAgedAged, 80 and overFemaleHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedPrognosisFluorodeoxyglucose F1818F-fluorodeoxyglucose positron emission tomography /computed tomography (18F-FDG PET/CT)Pancreatic adenocarcinoma (PAAD)Tertiary lymphoid structuresTumor microenvironment

Identifiers

PMID41128888
PMCPMC12549455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.