Evidence map›Paper›PMID 41128867›Full record

SynthesisNeuroradiology2025

Safety of mechanical thrombectomy in pediatric acute ischemic stroke: a systematic review and meta-analysis.

Lucca Tamara Alves Carretta, Ocilio Ribeiro Gonçalves, Lucas Copolillo Faria, Rafael Torres Fonseca Dos Santos, Mariana Lee Han, Wagner Rios-Garcia, Filipe Virgilio Ribeiro, Marianna Leite, Yasmin Picanço Silva, Adil Ahmed and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucca Tamara Alves CarrettaEscola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Brazil. luccatamara12@gmail.com.
Ocilio Ribeiro GonçalvesFederal University of Piauí, Teresina, Brazil.
Lucas Copolillo FariaEscola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Brazil.
Rafael Torres Fonseca Dos SantosMedical Education Institute Vista Carioca, Rio de Janeiro, Brazil.
Mariana Lee HanUniversidade de São Paulo, São Paulo, Brazil.
Wagner Rios-GarciaNational University of San Luis Gonzaga, Ica, Peru.
Filipe Virgilio RibeiroCentro Universitário Barão de Mauá, Ribeirão Preto, Brazil.
Marianna LeiteColégio Santa Marcelina, São Paulo, Brazil.
Yasmin Picanço SilvaHealthcare Institution of South Iceland, Selfoss, Iceland.
Adil AhmedNorthwest School of Medicine, Peshawar, Pakistan.
Nicole Baptista de OliveiraEscola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Brazil.
Ahmet GünkanDivision of Vascular and Interventional Radiology, Department of Radiology, University of Arizona, Tucson, United States.
Pascal JabbourThomas Jefferson University, Philadelphia, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis meta-analysis aimed to evaluate the clinical outcomes and safety of mechanical thrombectomy (MT) in pediatric acute ischemic stroke (AIS).

methodsSystematic search of PubMed, Embase and Cochrane Library identified studies on MT in children (≤ 18 years) with AIS. Data on baseline characteristics, procedural details and clinical outcomes, including favorable functional outcome (modified Rankin Scale [mRS] 0-2), National Institutes of Health Stroke Scale (NIHSS) reduction, Pediatric Stroke Outcome Measure (PSOM), symptomatic intracranial hemorrhage (sICH) and mortality were extracted. A single-arm meta-analysis was performed to estimate pooled rates.

results25 studies, encompassing 885 patients (mean age of included cohorts: 10.2-18 years), were included. The pooled favorable functional outcome was 80% (95% CI, 70%-88%), while the poor functional outcome was 14% (95% CI: 5%-26%). Mean NIHSS reduction was 8.07 (95% CI, 5.93-10.22), PedNIHSS decrease was 14.64 (95% CI: 12.04 to 17.24), and pooled mean PSOM score at follow-up was 1.02 (95% CI, 0.48-1.55). sICH was 2% (95% CI, 0-5%), need for decompressive hemicraniectomy was 7% (95% CI: 2%-14%) and overall mortality was 4% (95% CI, 1%-8%). Successful recanalization was 88% (95% CI: 81%-95%) and no reperfusion and re-occlusion were both 3% (95% CI: 0%-7%).

conclusionMT appears to be a promising and safe treatment option for pediatric AIS, demonstrating high rates of favorable functional outcomes and low mortality/sICH. However, significant heterogeneity among studies highlights the need for further high-quality, standardized research to optimize patient selection and define its effectiveness.

Indexed as

Ischemic StrokeMechanical ThrombolysisThrombectomyAdolescentChildHumansTreatment OutcomeAcute ischemic strokeChildhood strokeMechanical thrombectomyMeta-AnalysisPediatric stroke

Identifiers

PMID41128867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.