Evidence map›Paper›PMID 41128841›Full record

ArticleMicrobiologyOpen2025

Gallium Liquid Metal Nanoparticles as Agents to Treat Multidrug-Resistant Bacterial Infections.

Hang Thi Nguyen, Jiratchaya Puangseree, Tien Thanh Nguyen, Manh Tuong Nguyen, Christopher Leigh, Henrietta Venter, Krasimir Vasilev, Rungtip Chuanchuen, Darren J Trott, Vi Khanh Truong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hang Thi NguyenAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.
Jiratchaya PuangsereeResearch Unit for Microbial Food Safety and Antimicrobial Resistance, Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Tien Thanh NguyenBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Manh Tuong NguyenBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Christopher LeighAdelaide Microscopy, The University of Adelaide, Adelaide, South Australia, Australia.
Henrietta VenterHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Krasimir VasilevBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.ORCID https://orcid.org/0000-0003-3534-4754
Rungtip ChuanchuenResearch Unit for Microbial Food Safety and Antimicrobial Resistance, Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Darren J TrottAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.ORCID https://orcid.org/0000-0002-8297-5770
Vi Khanh TruongBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Abiodun David OgunniyiAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.

Funding

The authors acknowledge the instruments and scientific and technical assistance of Microscopy Australia at Adelaide Microscopy, The University of Adelaide, a facility that is funded by the university and state and federal governments. Jiratchaya Puangseree was supported by the Royal Golden Jubilee PhD program (Scholarship Number PHD/0194/2559).
6 · The paper itself

Abstract

Multidrug-resistant (MDR) bacterial infections constitute one of the top global public health threats. This study investigated the potential of gallium liquid metal nanoparticles (GaLM NPs) as a new agent against MDR pathogens. GaLM NPs was bactericidal against methicillin-resistant Staphylococcus aureus (MRSA) isolates and a vancomycin-intermediate S. aureus reference strain (minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values between 39 and 156 μg/mL). The bactericidal activity of GaLM NPs was supported by transmission electron microscopy showing marked ultrastructural changes in the cell envelope of MRSA USA300. GaLM NPs were bacteriostatic against selected Gram-negative (Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae) reference strains and isolates (MICs between 39 and 625 μg/mL). Furthermore, GaLM NPs demonstrated additive and bacteriostatic activity when combined with sub-inhibitory concentrations of colistin against P. aeruginosa isolates. Additionally, GaLM NPs showed anti-biofilm activity against MRSA USA300 (minimum biofilm eradication concentration of 625 μg/mL); morphology changes of GaLM NPs-treated cells was demonstrated by scanning electron microscopy. Finally, GaLM NPs was safe to human epidermal keratinocyte cell line at 1024 µg/mL (6.5 × MIC). We conclude that GaLM NPs warrant further exploration for the effective treatment of Gram-positive or Gram-negative infections both alone and in combination with antimicrobial drugs.

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialGalliumMetal NanoparticlesAcinetobacter baumanniiBiofilmsGram-Negative BacteriaHumansKlebsiella pneumoniaeMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionPseudomonas aeruginosaAnti-Bacterial AgentsGalliumbiofilmsgallium liquid metal nanoparticles, antimicrobial resistancescanning electron microscopysuperbugstransmission electron microscopy

Identifiers

PMID41128841
PMCPMC12548495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.