Evidence map›Paper›PMID 41128806›Full record

ArticleMolecular biology reports2025

NOS1AP: a potential subtype-specific dual role as a tumor suppressor and oncogene in breast cancer subtypes.

Büşra Polat, Gökçe Güllü Amuran, İrem Peker Eyüboğlu, Mustafa Ümit Uğurlu, Handan Kaya, Mustafa Akkiprik

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Büşra PolatDepartment of Medical Biology and Genetic, Institute of Health Sciences, Marmara University, İstanbul, Turkey.ORCID http://orcid.org/0000-0002-5707-7071
Gökçe Güllü AmuranDepartment of Medical Biology and Genetic, Institute of Health Sciences, Marmara University, İstanbul, Turkey.ORCID http://orcid.org/0000-0002-2267-2110
İrem Peker EyüboğluDepartment of Medical Biology and Genetic, Institute of Health Sciences, Marmara University, İstanbul, Turkey.ORCID http://orcid.org/0000-0003-0764-9841
Mustafa Ümit UğurluSchool of Medicine, Department of Surgical Medical Sciences, Marmara University, İstanbul, Turkey.ORCID http://orcid.org/0000-0002-4757-5560
Handan KayaSchool of Medicine, Department of Surgical Medical Sciences, Marmara University, İstanbul, Turkey.ORCID http://orcid.org/0000-0002-1147-4178
Mustafa AkkiprikDepartment of Medical Biology and Genetic, Institute of Health Sciences, Marmara University, İstanbul, Turkey. makkiprik@marmara.edu.tr.ORCID http://orcid.org/0000-0002-1100-765X

Funding

Marmara University Scientific Research Projects Coordination Unit - BAPKO Grant Number: TYL-2021-10165
6 · The paper itself

Abstract

backgroundNOS1AP/CAPON has been associated with neurological and cardiovascular diseases, but it has recently gained significant attention in cancer research. A limited number of studies conducted on breast cancer (BC) suggest that NOS1AP may possess both tumor suppressive and oncogenic potential. METHODS AND

resultsThis study is the first to investigate the relationship between NOS1AP and EMT (Epithelial-Mesenchymal Transition) in BC tissues and within distinct BC subtypes. Additionally, it provides a pioneering analysis of NOS1AP associations with Hippo pathway components across BC subtypes. The expression levels of NOS1AP, Hippo pathway genes, and EMT markers in primary tissues from different BC subtypes were analyzed using RT-PCR. While NOS1AP expression was reduced in basal BC tissues compared to normal adjacent tissues (NAT), in luminal B BC tissues, only NOS1AP and CDH1 expression showed a significant increase (p < 0.05). Correlation analyses suggest a potential association between NOS1AP, EMT markers, and components of the Hippo pathway. Bioinformatics analysis of overall survival (OS) curves revealed that high NOS1AP expression is associated with prolonged OS, irrespective of BC subtype.

conclusionsThese findings suggest that NOS1AP may play a dual role in a subtype-specific manner, potentially serving as a subtype-specific biomarker.

Indexed as

Adaptor Proteins, Signal TransducingBreast NeoplasmsBiomarkers, TumorCadherinsEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHippo Signaling PathwayHumansMiddle AgedOncogenesProtein Serine-Threonine KinasesSignal TransductionAdaptor Proteins, Signal TransducingBiomarkers, TumorCadherinsNOS1AP protein, humanProtein Serine-Threonine KinasesBreast cancer subtypesCAPONEpithelial-Mesenchymal transitionHippo pathwayNOS1AP

Identifiers

PMID41128806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.